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Table 1 Multivariable subdistribution hazard model for contralateral breast cancer risk

From: Prediction and clinical utility of a contralateral breast cancer risk model

Factor (category) at primary breast cancerMultivariable analysis
sHR95% CI
Age, years0.68*0.62–0.74*
Family history (yes versus no)1.351.27–1.45
BRCA mutation
BRCA1 versus non-carrier3.683.34–4.07
BRCA2 versus non-carrier2.562.36–2.78
Nodal status (positive versus negative)0.870.80–0.93
Tumor size, cm
 2.5 versus ≤ 20.950.89–1.02
 > 5 versus ≤ 21.140.99–1.31
Morphology (lobular including mixed versus ductal including others)1.231.14–1.34
Grade
 Moderately differentiated versus well differentiated0.890.82–0.96
 Poorly differentiated versus well differentiated0.750.70–0.82
Chemotherapy (yes versus no)0.770.70–0.84
Radiotherapy to the breast (yes versus no)1.010.95–1.08
ER (positive or negative)/endocrine therapy (yes or no)
 Negative/no versus positive/yes1.431.30–1.57
 Positive/no versus positive/yes1.751.61–1.90
HER2 (positive or negative)/trastuzumab therapy (yes or no)
 Negative/no versus positive/yes1.080.93–1.27
 Positive/no versus positive/yes0.990.83–1.18
  1. sHR subdistributional hazard ratio, CI confidence interval, ER estrogen receptor, HER2 human epidermal growth factor receptor 2. *Age was parameterized as a linear spline with one interior knot at 50 years. For representation purposes, we here provide the sHR for the 75th versus the 25th percentile. For more details about age parameterization, see also Additional file 3: Supplementary Methods