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Table 1 Summary of PDX models and metastatic potential. PDX breast cancer sub-types and metastasis status of patients from which cells were isolated

From: Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Model namePathologyTypeGradePDX model creationMetastasis status/site in patient
BB3RC31IDC (PE)Late breast cancer2Cells isolated from pleural effusionLung, liver and peritoneum at time of drain
BB3RC32IDC (Asc)Late breast cancer2Cells isolated from ascetic fluid sampleLiver, lung and peritoneum at time of drain.
BB2RC08IDCLate breast cancerUnknownCreated from primary breast tumourNo metastasis or recurrence to date.
BB6RC39IDCEarly breast cancer2Created from primary breast tumourNo metastasis or recurrence to date.
BB6RC37IDCEarly breast cancer3Created from primary breast tumourNo metastasis at time of PDX generation. Patient since diagnosed with metastasis to bone, liver and peri-pancreatic node.
BB6RC52IDCEarly breast cancer3Created from primary breast tumourNo metastasis at time of PDX generation. Patient since diagnosed with brain metastasis.