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Table 1 Summary of PDX models and metastatic potential. PDX breast cancer sub-types and metastasis status of patients from which cells were isolated

From: Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Model name

Pathology

Type

Grade

PDX model creation

Metastasis status/site in patient

BB3RC31

IDC (PE)

Late breast cancer

2

Cells isolated from pleural effusion

Lung, liver and peritoneum at time of drain

BB3RC32

IDC (Asc)

Late breast cancer

2

Cells isolated from ascetic fluid sample

Liver, lung and peritoneum at time of drain.

BB2RC08

IDC

Late breast cancer

Unknown

Created from primary breast tumour

No metastasis or recurrence to date.

BB6RC39

IDC

Early breast cancer

2

Created from primary breast tumour

No metastasis or recurrence to date.

BB6RC37

IDC

Early breast cancer

3

Created from primary breast tumour

No metastasis at time of PDX generation. Patient since diagnosed with metastasis to bone, liver and peri-pancreatic node.

BB6RC52

IDC

Early breast cancer

3

Created from primary breast tumour

No metastasis at time of PDX generation. Patient since diagnosed with brain metastasis.