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Fig. 4 | Breast Cancer Research

Fig. 4

From: Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Fig. 4

Effects of bone viability on breast cancer metastasis. Eight-week-old female NOD/SCID mice were implanted with femoral bone (mixed, spongy and subchondral) (a), subchondral only (b) or subchondral bone that had been devitalized prior to implantation (c). Four weeks after implantation of bone, all mice received injections of MDA-MB-231 breast cancer cells into mammary ducts 4 and 9; primary tumour growth and metastasis to human bone implants can be seen in a and b. Histogram (d) represents mean ± SEM of percentage of mice that developed metastases in human bone implants from 3 independent experiments each containing 10 mice/group, statistical significance determined by one-way ANOVA. **p < 0.001; ND, not detected

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