Fig. 1

Consensus clustering of 92 luminal breast tumors from Hong Kong patients based on 130 immune-related genes. a Consensus cluster matrix showing three major clusters. b Gene expression heatmap showing gene expression levels of 13 immune metagenes in the three luminal immune subtypes (low-TIL, high-ISG, and high-TIL) and in non-luminal (HER2-enriched and basal-like) tumors. Each column represents a patient, grouped by immune subtypes; each row represents a gene, grouped by 13 immune pathways. Normalized gene expression value with mean = 0 and standard deviation (SD) = 1 is indicated by 5 color categories representing the increasing expression level from green to red. LCK lymphocyte-specific protein tyrosine kinase, Tfh helper follicular T cell, Tregs regulatory T cell, NK natural killer cell, MHC major histocompatibility complex, STAT1 signal transducer and activator of transcription 1, IF_I interferon inducible genes (boxed for Lum2/high-ISG); PAM50: green = luminal A, blue = luminal B, gray = basal, black = HER2-enriched