TY - JOUR AU - Kenyon, Elizabeth AU - Westerhuis, Jennifer J. AU - Volk, Maximilian AU - Hix, Jeremy AU - Chakravarty, Shatadru AU - Claucherty, Ethan AU - Zaluzec, Erin AU - Ramsey, Lisa AU - Madaj, Zach AU - Hostetter, Galen AU - Eagleson, Bryn AU - Shapiro, Erik AU - Moore, Anna AU - Sempere, Lorenzo F. PY - 2019 DA - 2019/11/28 TI - Ductal tree ablation by local delivery of ethanol prevents tumor formation in an aggressive mouse model of breast cancer JO - Breast Cancer Research SP - 129 VL - 21 IS - 1 AB - Prophylactic mastectomy is the most effective intervention to prevent breast cancer. However, this major surgery has life-changing consequences at the physical, emotional, psychological, and social levels. Therefore, only high-risk individuals consider this aggressive procedure, which completely removes the mammary epithelial cells from which breast cancer arises along with surrounding tissue. Here, we seek to develop a minimally invasive procedure as an alternative to prophylactic mastectomy by intraductal (ID) delivery of a cell-killing solution that locally ablates the mammary epithelial cells before they become malignant. SN - 1465-542X UR - https://doi.org/10.1186/s13058-019-1217-x DO - 10.1186/s13058-019-1217-x ID - Kenyon2019 ER -