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Fig. 3 | Breast Cancer Research

Fig. 3

From: BRCA1 mutation influences progesterone response in human benign mammary organoids

Fig. 3

Differentially expressed genes in organoids from non-carrier and BRCA1-mutated tissues in response to hormones. a Principal component analysis (PCA) was done for the top 1% of variant genes in BRCA1mut (N = 8, hormone and hormone+TPA) shown in blue, and in non-carriers (N = 8, hormone and hormone+TPA) shown in orange. b Correlation dot plot of expression of top 3% of variant genes between BRCA1mut+TPA (N = 4) and non-carriers+TPA (N = 4) is shown. c Gene ontology (GO) analysis was done for variant genes comparing different groups. p value *p < 0.05. d GSEA plot of extracellular matrix organization (p = 0.00012; NES = − 2.2987) shows the ECM organization signature is negatively enriched in BRCA1mut tissues treated with E2+P4+TPA (N = 4) versus E2+P4 (N = 4). e Log2 fold change of extracellular organization genes in BRCA1mut tissues treated with E2+P4+TPA (N = 4) versus E2+P4 (N = 4) is listed

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