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Table 4 Adjusted hazard ratios and 95% confidence intervals from Cox proportional hazards modeling of smoking status stratified by alcohol consumption

From: Alcohol consumption, cigarette smoking, and familial breast cancer risk: findings from the Prospective Family Study Cohort (ProF-SC)

 Overall BCER-positive BCER-negative BC
Continuous FRPPerson yearsBCModel 1aModel 2bBCModel 1aModel 2bBCModel 1aModel 2b
HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)
 Regular drinkersd
  Never smoker40,334.3216ReferenceReference90ReferenceReference24ReferenceReference
  Former smoker31,831.42191.16 (0.96, 1.41)1.23 (0.99, 1.53)971.24 (0.93, 1.65)1.25 (0.89, 1.75)241.17 (0.64, 2.17)1.08 (0.55, 2.12)
  Current smoker16,742.8901.07 (0.83, 1.36)0.84 (0.63, 1.13)351.12 (0.76, 1.65)0.99 (0.62, 1.60)201.77 (0.91, 3.46)0.95 (0.43, 2.07)
  Former smoker*FRP   0.93 (0.78, 1.09)  0.99 (0.74, 1.34)  1.10 (0.83, 1.46)
  Current smoker*FRP   1.39 (1.13, 1.71)  1.21 (0.80, 1.85)  1.67 (1.16, 2.40)
 Non-regular drinkers
  Never smoker62,284.47343ReferenceReference145ReferenceReference61ReferenceReference
  Former smoker15,157.38830.88 (0.69, 1.12)0.90 (0.67, 1.21)210.54 (0.34, 0.86)0.63 (0.36, 1.10)150.95 (0.53, 1.72)0.93 (0.45, 1.89)
  Current smoker9692.36470.97 (0.71, 1.32)1.00 (0.69, 1.46)190.98 (0.61, 1.59)1.04 (0.59, 1.84)70.77 (0.34, 1.74)0.68 (0.23, 1.97)
  Former smoker*FRPe   0.98 (0.81, 1.17)  0.82 (0.54, 1.25)  1.02 (0.77, 1.35)
  Current smoker*FRPe   0.95 (0.70, 1.29)  0.93 (0.61, 1.42)  1.11 (0.69, 1.79)
Categorical FRP1-year FRP < 0.34%1-year FRP ≥ 0.34%1-year FRP < 0.34%1-year FRP ≥ 0.34% 1-year FRP < 0.34%1-year FRP ≥ 0.34%
HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI) HR (95% CI)HR (95% CI)
 Regular drinkers
  Former smoker1.16 (0.85, 1.59)1.16 (0.92, 1.47)1.04 (0.64, 1.69)1.32 (0.93, 1.88)0.60 (0.15, 2.44)1.38 (0.71, 2.7)
  Current smoker0.81 (0.51, 1.27)1.25 (0.94, 1.68)0.87 (0.42, 1.78)1.28 (0.80, 2.04)0.70 (0.13, 3.63)1.99 (0.98, 4.03)
 Non-regular drinkers
  Former smoker0.88 (0.54, 1.42)0.89 (0.67, 1.18)0.68 (0.28, 1.65)0.52 (0.30, 0.90)1.61 (0.45, 5.77)0.83 (0.44, 1.57)
  Current smoker1.11 (0.65, 1.90)0.91 (0.62, 1.35)0.97 (0.39, 2.45)1.06 (0.60, 1.88)1.10 (0.22, 5.43)0.66 (0.26, 1.68)
  1. BC breast cancer, HR hazard ratio, CI confidence interval, ER estrogen receptor expression, FRP familial risk profile
  2. aModel 1 = Adjusted Cox models which are stratified by birth cohort (< 1950, 1950–1959, 1960–1969, ≥ 1970) and adjusted for study site, race/ethnicity, body mass index, education, and hormonal birth control use
  3. bModel 2 = Interaction models that include an interaction term with FRP as estimated by 1-year BOADICEA risk score
  4. cSmokers are defined as having smoked at least one cigarette per day for 3 months or longer
  5. dRegular drinkers are defined as consuming one alcoholic beverage at least once a week for 6 months or longer