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Table 4 Adjusted hazard ratios and 95% confidence intervals from Cox proportional hazards modeling of smoking status stratified by alcohol consumption

From: Alcohol consumption, cigarette smoking, and familial breast cancer risk: findings from the Prospective Family Study Cohort (ProF-SC)

 

Overall BC

ER-positive BC

ER-negative BC

Continuous FRP

Person years

BC

Model 1a

Model 2b

BC

Model 1a

Model 2b

BC

Model 1a

Model 2b

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

 Regular drinkersd

  Never smoker

40,334.3

216

Reference

Reference

90

Reference

Reference

24

Reference

Reference

  Former smoker

31,831.4

219

1.16 (0.96, 1.41)

1.23 (0.99, 1.53)

97

1.24 (0.93, 1.65)

1.25 (0.89, 1.75)

24

1.17 (0.64, 2.17)

1.08 (0.55, 2.12)

  Current smoker

16,742.8

90

1.07 (0.83, 1.36)

0.84 (0.63, 1.13)

35

1.12 (0.76, 1.65)

0.99 (0.62, 1.60)

20

1.77 (0.91, 3.46)

0.95 (0.43, 2.07)

  Former smoker*FRP

   

0.93 (0.78, 1.09)

  

0.99 (0.74, 1.34)

  

1.10 (0.83, 1.46)

  Current smoker*FRP

   

1.39 (1.13, 1.71)

  

1.21 (0.80, 1.85)

  

1.67 (1.16, 2.40)

 Non-regular drinkers

  Never smoker

62,284.47

343

Reference

Reference

145

Reference

Reference

61

Reference

Reference

  Former smoker

15,157.38

83

0.88 (0.69, 1.12)

0.90 (0.67, 1.21)

21

0.54 (0.34, 0.86)

0.63 (0.36, 1.10)

15

0.95 (0.53, 1.72)

0.93 (0.45, 1.89)

  Current smoker

9692.36

47

0.97 (0.71, 1.32)

1.00 (0.69, 1.46)

19

0.98 (0.61, 1.59)

1.04 (0.59, 1.84)

7

0.77 (0.34, 1.74)

0.68 (0.23, 1.97)

  Former smoker*FRPe

   

0.98 (0.81, 1.17)

  

0.82 (0.54, 1.25)

  

1.02 (0.77, 1.35)

  Current smoker*FRPe

   

0.95 (0.70, 1.29)

  

0.93 (0.61, 1.42)

  

1.11 (0.69, 1.79)

Categorical FRP

1-year FRP < 0.34%

1-year FRP ≥ 0.34%

1-year FRP < 0.34%

1-year FRP ≥ 0.34%

 

1-year FRP < 0.34%

1-year FRP ≥ 0.34%

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

 

HR (95% CI)

HR (95% CI)

 Regular drinkers

  Former smoker

1.16 (0.85, 1.59)

1.16 (0.92, 1.47)

1.04 (0.64, 1.69)

1.32 (0.93, 1.88)

0.60 (0.15, 2.44)

1.38 (0.71, 2.7)

  Current smoker

0.81 (0.51, 1.27)

1.25 (0.94, 1.68)

0.87 (0.42, 1.78)

1.28 (0.80, 2.04)

0.70 (0.13, 3.63)

1.99 (0.98, 4.03)

 Non-regular drinkers

  Former smoker

0.88 (0.54, 1.42)

0.89 (0.67, 1.18)

0.68 (0.28, 1.65)

0.52 (0.30, 0.90)

1.61 (0.45, 5.77)

0.83 (0.44, 1.57)

  Current smoker

1.11 (0.65, 1.90)

0.91 (0.62, 1.35)

0.97 (0.39, 2.45)

1.06 (0.60, 1.88)

1.10 (0.22, 5.43)

0.66 (0.26, 1.68)

  1. BC breast cancer, HR hazard ratio, CI confidence interval, ER estrogen receptor expression, FRP familial risk profile
  2. aModel 1 = Adjusted Cox models which are stratified by birth cohort (< 1950, 1950–1959, 1960–1969, ≥ 1970) and adjusted for study site, race/ethnicity, body mass index, education, and hormonal birth control use
  3. bModel 2 = Interaction models that include an interaction term with FRP as estimated by 1-year BOADICEA risk score
  4. cSmokers are defined as having smoked at least one cigarette per day for 3 months or longer
  5. dRegular drinkers are defined as consuming one alcoholic beverage at least once a week for 6 months or longer
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Breast Cancer Research

ISSN: 1465-542X

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