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Table 3 Adjusted hazard ratios and 95% confidence intervals from Cox proportional hazards modeling of alcohol consumption

From: Alcohol consumption, cigarette smoking, and familial breast cancer risk: findings from the Prospective Family Study Cohort (ProF-SC)

 

Overall BC

ER-positive BC

ER-negative BC

Continuous FRP

Person years

BC

Model 1a

Model 2b

BC

Model 1a

Model 2b

BC

Model 1a

Model 2b

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

 Non-regular drinkerc

90,009.0

492

Reference

Reference

192

Reference

Reference

85

Reference

Reference*

 < 7 drinks/week

48,947.2

275

0.99 (0.85, 1.16)

1.01 (0.84, 1.21)

122

1.07 (0.84, 1.36)

1.14 (0.85, 1.52)

36

0.69 (0.46, 1.04)

0.64 (0.40, 1.04)

 ≥ 7 drinks/week

29,982.8

193

1.10 (0.92, 1.32)

1.22 (0.99, 1.50)

80

1.15 (0.87, 1.51)

1.48 (1.08, 2.02)

30

0.89 (0.57, 1.39)

0.84 (0.51, 1.40)

 < 7 drinks/week*FRP

   

0.99 (0.87, 1.12)

  

0.92 (0.74, 1.15)

  

1.06 (0.87, 1.29)

 ≥ 7 drinks/week*FRP

   

0.88 (0.76, 1.01)

  

0.68 (0.52, 0.89)

  

1.04 (0.85, 1.27)

Categorical FRP

1-year FRP < 0.34%

1-year FRP ≥ 0.34%

1-year FRP < 0.34%

1-year FRP ≥ 0.34%

1-year FRP < 0.34%

1-year FRP ≥ 0.34%

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

 Non-regular drinker

Reference

Reference

Reference

Reference

Reference

Reference

 < 7 drinks/week

1.02 (0.77, 1.35)

0.96 (0.79, 1.16)

0.99 (0.64, 1.54)

1.10 (0.82, 1.48)

0.69 (0.26, 1.87)

0.65 (0.41, 1.03)

 ≥ 7 drinks/week

1.18 (0.87, 1.61)

1.05 (0.84, 1.31)

1.24 (0.76, 2.01)

1.09 (0.77, 1.53)

0.43 (0.13, 1.49)

0.98 (0.61, 1.58)

  1. BC breast cancer, HR hazard ratio, CI confidence interval, ER estrogen receptor expression, FRP familial risk profile
  2. aModel 1 = Adjusted Cox models which are stratified by birth cohort (< 1950, 1950–1959, 1960–1969, ≥ 1970) and adjusted for study site, race/ethnicity, body mass index, education, hormonal birth control use, and cigarette smoking
  3. bModel 2 = Interaction models that include an interaction term with FRP as estimated by 1-year BOADICEA risk score
  4. cRegular drinkers are defined as consuming one alcoholic beverage at least once a week for 6 months or longer
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Breast Cancer Research

ISSN: 1465-542X

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