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Table 3 Adjusted hazard ratios and 95% confidence intervals from Cox proportional hazards modeling of alcohol consumption

From: Alcohol consumption, cigarette smoking, and familial breast cancer risk: findings from the Prospective Family Study Cohort (ProF-SC)

 Overall BCER-positive BCER-negative BC
Continuous FRPPerson yearsBCModel 1aModel 2bBCModel 1aModel 2bBCModel 1aModel 2b
HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)
 Non-regular drinkerc90,009.0492ReferenceReference192ReferenceReference85ReferenceReference*
 < 7 drinks/week48,947.22750.99 (0.85, 1.16)1.01 (0.84, 1.21)1221.07 (0.84, 1.36)1.14 (0.85, 1.52)360.69 (0.46, 1.04)0.64 (0.40, 1.04)
 ≥ 7 drinks/week29,982.81931.10 (0.92, 1.32)1.22 (0.99, 1.50)801.15 (0.87, 1.51)1.48 (1.08, 2.02)300.89 (0.57, 1.39)0.84 (0.51, 1.40)
 < 7 drinks/week*FRP   0.99 (0.87, 1.12)  0.92 (0.74, 1.15)  1.06 (0.87, 1.29)
 ≥ 7 drinks/week*FRP   0.88 (0.76, 1.01)  0.68 (0.52, 0.89)  1.04 (0.85, 1.27)
Categorical FRP1-year FRP < 0.34%1-year FRP ≥ 0.34%1-year FRP < 0.34%1-year FRP ≥ 0.34%1-year FRP < 0.34%1-year FRP ≥ 0.34%
HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)
 Non-regular drinkerReferenceReferenceReferenceReferenceReferenceReference
 < 7 drinks/week1.02 (0.77, 1.35)0.96 (0.79, 1.16)0.99 (0.64, 1.54)1.10 (0.82, 1.48)0.69 (0.26, 1.87)0.65 (0.41, 1.03)
 ≥ 7 drinks/week1.18 (0.87, 1.61)1.05 (0.84, 1.31)1.24 (0.76, 2.01)1.09 (0.77, 1.53)0.43 (0.13, 1.49)0.98 (0.61, 1.58)
  1. BC breast cancer, HR hazard ratio, CI confidence interval, ER estrogen receptor expression, FRP familial risk profile
  2. aModel 1 = Adjusted Cox models which are stratified by birth cohort (< 1950, 1950–1959, 1960–1969, ≥ 1970) and adjusted for study site, race/ethnicity, body mass index, education, hormonal birth control use, and cigarette smoking
  3. bModel 2 = Interaction models that include an interaction term with FRP as estimated by 1-year BOADICEA risk score
  4. cRegular drinkers are defined as consuming one alcoholic beverage at least once a week for 6 months or longer