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Table 1 Descriptive characteristics of women in the Breast Cancer Prospective Family Study Cohort (ProF-SC) by smoking status and alcohol consumption

From: Alcohol consumption, cigarette smoking, and familial breast cancer risk: findings from the Prospective Family Study Cohort (ProF-SC)

 Non-smoker (N = 10,158)Former smoker (N = 4675)Current smoker (N = 2602)Non-regular drinker (N = 8817)Regular drinker (N = 8618)Total cohort (N = 17,435)
Age at baseline (mean, SD)46.5 ± 15.649.2 ± 14.243.6 ± 14.048.0 ± 15.745.5 ± 14.346.8 ± 15.1
Age at breast cancer diagnosis (mean, SD)55.9 ± 12.258.2 ± 12.352.9 ± 11.557.0 ± 12.255.5 ± 12.356.2 ± 12.3
BOADICEA full lifetime risk score, % (mean, SD)23.8 ± 17.222.7 ± 15.423.3 ± 16.323.6 ± 17.123.2 ± 16.023.4 ± 16.6
BOADICEA 1-year risk score, % (mean, SD)0.5 ± 0.60.5 ± 0.60.4 ± 0.60.5 ± 0.70.4 ± 0.60.5 ± 0.6
BOADICEA 5-year risk score, % (mean, SD)2.4 ± 3.12.6 ± 3.12.2 ± 2.82.5 ± 3.22.4 ± 2.92.4 ± 3.0
Body mass index, kg/m2 (mean, SD)25.8 ± 5.626.3 ± 5.725.3 ± 5.726.5 ± 5.925.2 ± 5.325.8 ± 5.7
Cigarette smoking variables
 Age at smoking initiation, years (mean, SD)NA18.7 ± 5.218.1 ± 5.418.9 ± 6.018.3 ± 4.818.5 ± 5.3
 Smoking duration, years smoked (mean, SD)NA14.5 ± 11.623.9 ± 13.419.0 ± 13.617.0 ± 12.717.7 ± 13.1
 Smoking intensity, cigarettes/day (mean, SD)NA13.1 ± 10.815.1 ± 9.314.0 ± 10.613.7 ± 10.113.8 ± 10.3
Smoking intensity, cigarettes/day (n, %)
 Non-smokera10,158 (100.0)NANA6286 (71.3)3872 (44.9)10,158 (58.3)
 1 to < 5 cig/dayNA992 (21.2)242 (9.3)413 (4.7)821 (9.5)1234 (7.1)
 5 to < 10 cig/dayNA888 (19.0)421 (16.2)440 (5.0)869 (10.1)1309 (7.5)
 10 to < 20 cig/dayNA1321 (28.3)936 (36.0)823 (9.3)1434 (16.6)2257 (13.0)
 ≥ 20 more cig/dayNA1434 (30.7)980 (37.7)830 (9.4)1584 (18.4)2414 (13.9)
 Missing040 (0.9)23 (0.9)25 (0.3)38 (0.4)63 (0.4)
Smoking duration, years smoked (n, %)
 Non-smoker10,158 (100.0)NANA6286 (71.3)3872 (44.9)10,158 (58.3)
 < 10 yearsNA1900 (40.6)388 (14.9)728 (8.3)1560 (18.1)2288 (13.1)
 10 to < 20 yearsNA1367 (29.2)582 (22.4)621 (7.0)1328 (15.4)1949 (11.2)
 20 to < 30 yearsNA701 (15.0)646 (24.8)507 (5.8)840 (9.8)1347 (7.7)
 ≥ 30 yearsNA622 (13.3)821 (31.6)585 (6.6)858 (10.0)1443 (8.3)
 Missing085 (1.8)165 (6.3)90 (1.0)160 (1.9)250 (1.4)
Alcohol consumption variables
 Total drinks per week (mean, SD)6.0 ± 7.08.0 ± 10.110.9 ± 14.0NA7.7 ± 10.07.7 ± 10.0
 Age at drinking initiation (mean, SD)25.5 ± 11.023.7 ± 9.822.8 ± 8.6NA24.4 ± 10.224.4 ± 10.2
 Drinking duration, years (mean, SD)15.2 ± 12.018.8 ± 12.916.0 ± 11.8NA16.6 ± 12.416.6 ± 12.4
Categorical drinks per week (n, %)
 Non-regular drinkerc6406 (63.1)1686 (36.1)986 (37.9)8817 (100%)261 (3.0)c9078 (52.1)
 < 7 drinks/week2420 (23.8)1654 (35.4)763 (29.3)NA4837 (56.1)4837 (27.7)
 ≥ 7 drinks/week1095 (10.8)1158 (24.8)725 (27.9)NA2978 (34.6)2978 (17.1)
 Missing237 (2.3)177 (3.8)128 (4.9)NA542 (6.3)542 (3.1)
BRCA mutation carriers
 Non-carrier9374 (92.3)4405 (94.2)2430 (93.4)8148 (92.4)8061 (93.5)16,209 (93.0)
BRCA1 carrier417 (4.1)156 (3.3)105 (4.0)366 (4.2)312 (3.6)678 (3.9)
BRCA2 carrier367 (3.6)114 (2.4)67 (2.6)303 (3.4)245 (2.8)548 (3.1)
Study center
 Philadelphia444 (4.4)246 (5.3)94 (3.6)420 (4.8)364 (4.2)784 (4.5)
 New York1211 (11.9)616 (13.2)171 (6.6)1074 (12.2)924 (10.7)1998 (11.5)
 Utah666 (6.6)64 (1.4)38 (1.5)617 (7.0)151 (1.8)768 (4.4)
 Australia2147 (21.1)1046 (22.4)725 (27.9)1864 (21.1)2054 (23.8)3918 (22.5)
 Ontario, Canada1241 (12.2)703 (15.0)418 (16.1)1160 (13.2)1202 (14.0)2362 (13.6)
 Northern California1892 (18.6)679 (14.5)380 (14.6)1924 (21.8)1027 (11.9)2951 (16.9)
 kConFab2557 (25.2)1321 (28.3)776 (29.8)1758 (19.9)2896 (33.6)4654 (26.7)
Birth cohort
 < 19503917 (38.6)2108 (45.1)797 (30.6)3795 (43.0)3027 (35.1)6822 (39.1)
 1950–19592291 (22.6)1151 (24.6)666 (25.6)1975 (22.4)2133 (24.8)4108 (23.6)
 1960–19692002 (19.7)904 (19.3)638 (24.5)1590 (18.0)1954 (22.7)3544 (20.3)
 ≥ 19701948 (19.2)512 (11.0)501 (19.3)1457 (16.5)1504 (17.5)2961 (17.0)
Race
 Non-Hispanic White7803 (76.8)3998 (85.5)2158 (82.9)6397 (72.6)7562 (87.8)13,959 (80.1)
 Non-Hispanic Black481 (4.7)170 (3.6)158 (6.1)499 (5.7)310 (3.6)809 (4.6)
 Hispanic1012 (10.0)287 (6.1)137 (5.3)1057 (12.0)379 (4.4)1436 (8.2)
 Asian569 (5.6)64 (1.4)32 (1.2)545 (6.2)120 (1.4)665 (3.8)
 Other244 (2.4)135 (2.9)94 (3.6)271 (3.1)202 (2.3)473 (2.7)
 Missing49 (0.5)21 (0.5)23 (0.9)48 (0.5)45 (0.5)93 (0.5)
Education
 High school graduate or less3161 (18.1)1515 (8.7)1139 (6.5)3391 (38.5)2424 (28.1)5815 (33.4)
 Some college/vocational school3656 (21.0)1838 (10.5)1106 (6.3)3166 (35.9)3434 (39.9)6600 (37.9)
 Bachelor’s/graduate degree3296 (18.9)1311 (7.5)342 (2.0)2213 (25.1)2736 (31.8)4949 (28.4)
 Missing45 (0.3)11 (0.1)15 (0.1)47 (0.5)24 (0.3)71 (0.4)
Parity (number of full-term pregnancies/breastfeeding history)
 Nulliparous2617 (15.0)871 (5.0)660 (3.8)1857 (21.1)2291 (26.6)4148 (23.8)
 Parous 1–2/no breastfeeding1037 (6.0)586 (3.4)410 (2.4)1140 (12.9)893 (10.4)2033 (11.7)
 Parous 1–2/breastfed2626 (15.1)1395 (8.0)667 (3.8)2085 (23.7)2603 (30.2)4688 (26.9)
 Parous 3+/no breastfeeding758 (4.4)390 (2.2)256 (1.5)854 (9.7)550 (6.4)1404 (8.1)
 Parous 3+/breastfed3047 (17.5)1387 (8.0)591 (3.4)2820 (32.0)2205 (25.6)5025 (28.8)
 Missing73 (0.4)46 (0.3)18 (0.1)61 (0.7)76 (0.9)137 (0.8)
Hormonal birth control us
 Never2832 (16.2)933 (5.4)469 (2.7)2756 (31.3)1478 (17.2)4234 (24.3)
 Former5825 (33.4)3194 (18.3)1722 (9.9)5017 (56.9)5724 (66.4)10,741 (61.6)
 Current1424 (8.2)513 (2.9)393 (2.3)970 (11.0)1360 (15.8)2330 (13.4)
 Missing77 (0.4)35 (0.2)18 (0.1)74 (0.8)56 (0.7)130 (0.8)
  1. NA not applicable
  2. aSmokers are defined as having smoked at least once cigarette per day for 3 months or longer
  3. bRegular drinkers are defined as consuming one alcoholic beverage at least once a week for 6 months or longer
  4. cThis includes women who reported being regular drinkers that consumed 0 drinks per week. These women were categorized as non-regular drinkers in the categorical drinks per week variable