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Fig. 7 | Breast Cancer Research

Fig. 7

From: The atypical cyclin-like protein Spy1 overrides p53-mediated tumour suppression and promotes susceptibility to breast tumourigenesis

Fig. 7

Mechanism for increased susceptibility by elevation of Spy1. The left panel reflects that Spy1 protein levels are held in check by wild-type p53 to allow tightly regulated bursts of needed mammary proliferation during development. The panel to the right reflects the situation when either p53 is mutated/deleted or Spy1 protein levels are elevated, supporting susceptibility to tumourigenesis

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Breast Cancer Research

ISSN: 1465-542X

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