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Fig. 3 | Breast Cancer Research

Fig. 3

From: Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress

Fig. 3

Loss of SIM2s disrupts DNA replication. a Representative images showing normal, bridging, lagging, and acentric chromosomes during mitosis. MCF7-shSIM2 and MCF7-pSIL cells were synchronized and fixed during anaphase before being analyzed for the presence of b bridging strands, c lagging strands, and d acentric chromosomes. Likelihood ratio and Pearson’s chi-squared tests were performed to test correlations. n = 20. Scale bar, 10 μm. *p value < 0.05

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