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Table 4 List of image features in the entire tumour and intratumoural subregions and the correlations with gene expression modules

From: Tumour heterogeneity revealed by unsupervised decomposition of dynamic contrast-enhanced magnetic resonance imaging is associated with underlying gene expression patterns and poor survival in breast cancer patients

Type

Module

Feature

Entire tumour

 Entire tumour

Tan (n = 158)

Kurtosis† (r = 0.67)

Magenta (n = 198)

Volume† (r = 0.6), compactness† (r = 0.52)

Tumour subregions

 Plasma input

Tan (n = 158)

Kurtosis† (r = 0.7); volume† (r = 0.76); energy† (r = 0.55)

Magenta (n = 198)

Compactness† (r = 0.54)

 Fast-flow kinetics

Tan (n = 158)

Kurtosis† (r = 0.68); energy† (r = 0.56); Maximum probability† (r = 0.59)

Green yellow (n = 166)

Energy‡ (r = 0.58); maximum probability‡ (r = 0.52)

 Slow-flow kinetics

Tan (n = 158)

Kurtosis† (r = 0.55); energy† (r = 0.6); Maximum probability† (r = 0.53)

Magenta (n = 198)

Compactness† (r = 0.59)

  1. Only image features that have a high correlation (r > 0.5) with the gene module are shown. The image features with prognostic implications are in bold
  2. †Precontrast series (S-0)
  3. ‡Subtraction between the early postcontrast and precontrast series (S-1)