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Table 3 Image features for survival analysis in the reproducibility cohort

From: Tumour heterogeneity revealed by unsupervised decomposition of dynamic contrast-enhanced magnetic resonance imaging is associated with underlying gene expression patterns and poor survival in breast cancer patients

Feature

Recurrence-free survival

Overall survival

HR (95% CI)

p

FDR

HR (95% CI)

p

FDR

Volume †

1.5 (1.2–1.8)

< 10−3

0.003

1.6 (1.3–2)

< 10−4

< 10−3

Maximum probability †

1.3 (1.1–1.6)

0.012

0.042

1.4 (1.1–1.7)

0.001

0.006

Median‡

0.98 (0.73–1.3)

0.890

0.890

0.89 (0.56–1.4)

0.630

0.969

Median†

1 (0.78–1.4)

0.840

0.890

0.97 (0.67–1.4)

0.890

0.969

Compactness †

1.5 (1.2–1.9)

0.002

0.011

1.7 (1.3–2.2)

< 10−4

< 10−3

Energy †

1.3 (1.1–1.5)

0.012

0.042

1.3 (1.1–1.6)

0.003

0.009

Skewness†

1.1 (0.81–1.4)

0.580

0.677

1.3 (0.92–1.8)

0.150

0.300

Correlation†

1.2 (0.87–1.6)

0.290

0.543

1.1 (0.75–1.5)

0.690

0.969

Correlation‡

1.2 (0.89–1.7)

0.210

0.490

1.4 (0.91–2)

0.130

0.300

Maximum probability‡

0.9 (0.65–1.2)

0.520

0.662

1 (0.71–1.4)

0.980

0.980

 Kurtosis‡

0.87 (0.59–1.3)

0.490

0.662

0.98 (0.67–1.4)

0.900

0.969

 Energy‡

0.84 (0.57–1.2)

0.380

0.591

0.95 (0.65–1.4)

0.780

0.969

 Kurtosis†

1.2 (1–1.5)

0.031

0.087

1.3 (1.1–1.5)

0.010

0.028

 Skewness‡

0.84 (0.6–1.2)

0.310

0.543

1 (0.73–1.4)

0.890

0.969

  1. p values were adjusted by the Benjamini-Hochberg method
  2. The image features that are significantly associated with RFS and OS are shown in italics
  3. HR hazard ratio, CI confidence intervals
  4. †Precontrast series (S-0)
  5. ‡Subtraction between the early postcontrast and precontrast series (S-1)