Tumour heterogeneity revealed by unsupervised decomposition of dynamic contrast-enhanced magnetic resonance imaging is associated with underlying gene expression patterns and poor survival in breast cancer patients

Table 2 Image features for survival analysis

Feature	Beta	HR (95% CI)	Wald test	p value	Corrected p
Volume^†	0.47	1.6 (1.2–2.2)	8.4	0.004	0.024
Maximum probability^†	0.46	1.6 (1.1–2.2)	7.9	0.005	0.024
Median^‡	0.44	1.6 (1.1–2.1)	7.6	0.006	0.024
Median^†	0.44	1.6 (1.1–2.1)	7.3	0.007	0.024
Compactness^†	0.43	1.5 (1.1–2.2)	6.4	0.011	0.031
Energy^†	0.34	1.4 (1.0–1.9)	5.2	0.023	0.054
Skewness^†	− 0.56	0.57 (0.3–1.1)	2.9	0.087	0.170
Correlation^†	0.25	1.3 (0.85–1.9)	1.4	0.230	0.400
Correlation^‡	0.24	1.3 (0.79–2.0)	1.0	0.320	0.500
Maximum probability^‡	− 0.11	0.9 (0.57–1.4)	0.20	0.650	0.820
Kurtosis^‡	0.086	1.1 (0.72–1.7)	0.16	0.690	0.820
Energy^‡	0.073	1.1 (0.75–1.6)	0.15	0.700	0.820
Kurtosis^†	0.047	1.0 (0.76–1.4)	0.08	0.770	0.830
Skewness^‡	− 0.014	0.99 (0.67–1.4)	0	0.940	0.940

ISSN: 1465-542X