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Table 1 Demographics of the study cohorts

From: Tumour heterogeneity revealed by unsupervised decomposition of dynamic contrast-enhanced magnetic resonance imaging is associated with underlying gene expression patterns and poor survival in breast cancer patients

Parameter Training cohort (n = 61) Reproducibility cohort (n = 173) Radiogenomic cohort (n = 87) TCGA cohort (n = 1010)
Age (years)
 Median 48 (29.7–72.4) 47.8 (26.7–68.8) 52 (29–82) 59 (26–90)
 Mean ± SD 48.1 ± 9.8 47.7 ± 8.8 53.3 ± 11.3 58.9 ± 13.2
Race
 Asian 3 (5) 7 (4) 0 61 (6)
 Black or African-American 3 (5) 30 (17) 4 (5) 180 (18)
 White 47 (77) 135 (78) 82 (94) 675 (67)
 Unknown or others 8 (13) 1 (1) 1 (1) 94 (9)
Oestrogen receptor status
 Positive 28 (46) 97 (56) 75 (86) 733 (73)
 Negative 20 (33) 74 (43) 12 (14) 226 (22)
 Indeterminate 0 0 0 2 (0)
 Unknown 13 (21) 2 (1) 0 49 (5)
Progesterone receptor status
 Positive 22 (36) 81 (47) 69 (79) 630 (63)
 Negative 26 (43) 90 (52) 18 (21) 326 (32)
 Indeterminate 0 0 0 4 (0)
 Unknown 13 (21) 2 (1) 0 50 (5)
Human epidermal growth factor receptor 2 status
 Positive 14 (23) 102 (59) 15 (17) 149 (15)
 Negative 31 (51) 69 (40) 46 (53) 518 (51)
 Equivocal 0 0 19 (22) 172 (17)
 Unknown 16 (26) 2 (1) 7 (8) 171 (17)
Histological type
 Infiltrating ductal 37 (60) N/A 75 (86) 709 (70)
 Infiltrating lobular 12 (20) N/A 10 (12) 193 (19)
 Others 12 (20) N/A 2 (2) 107 (11)
 Unknown 0 N/A 0 1 (0)
Follow-up (years)
 Median 5.39 (0.28–9.84) 3.91 (0.51–6.76) 3.48 (0.37–9.40) 1.15 (0.03–19.36)
 Mean ± SD 4.77 ± 2.749 3.85 ± 1.46 3.93 ± 2.22 2.37 ± 2.94
Recurrence
 Event 23 (38) 49 (28) 5 (6) 97 (10)
 No event 38 (62) 124 (72) 67 (77) 674 (67)
 Unknown 0 0 15 (17) 239 (23)
Death
 Event N/A 32 (18) 1 (1) 104 (10)
 No event N/A 138 (80) 86 (99) 906 (90)
 Unknown N/A 3 (2) 0 0
  1. Numbers in parentheses are percentages
  2. ER oestrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2