| |
Ipsilateral change**
|
Contralateral change**
|
Difference
|
p value
|
|---|
|
Tumors ≤ 2 cm (N = 860)
|
|
VPD (%)
|
− 0.30 (− 1.24, 0.65)
|
− 0.32 (− 1.26, 0.47)
|
0.07 (− 0.74, 0.87)
|
0.23
|
|
DV (cm3)
|
− 2.52 (− 9.70, 3.98)
|
− 2.72 (− 9.51, 3.35)
|
0.02 (− 6.62, 7.03)
|
0.76
|
|
Tumors 2–5 cm (N = 243)
|
|
VPD (%)
|
− 0.18 (− 1.67, 0.93)
|
− 0.67 (− 2.00, 0.20)
|
0.40 (− 0.66, 1.63)
|
< .001
|
|
DV (cm3)
|
− 0.93 (− 10.04, 9.64)
|
− 3.03 (− 12.97, 3.49)
|
4.15 (− 4.83, 13.09)
|
< .001
|
|
Tumors > 5 cm (N = 36)
|
|
VPD (%)
|
0.34 (− 1.27, 2.13)
|
− 0.45 (− 1.74, 0.04)
|
1.18 (0.02, 2.47)
|
< .001
|
|
DV (cm3)
|
11.78 (− 0.99, 25.14)
|
− 3.12 (− 9.53, 1.97)
|
12.97 (2.72, 24.89)
|
< .001
|
- VPD volumetric percent density, DV dense volume
- **Change was calculated by subtracting the density at the earliest mammogram from the density at the mammogram closest to diagnosis. A negative value reflects a decrease over time
