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Table 2 Median (interquartile range) changes in volumetric density measures by breast side and differences between sides, cases, and controls, overall and stratified on BI-RADS density

From: Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer

  Cases Controls
Ipsilateral change* Contralateral change* Difference p value Ipsilateral change* Contralateral change* Difference p value
Overall (n = 1160 cases/2360 controls)
 VPD (%) − 0.26 (− 1.34, 0.70) − 0.39 (− 1.39, 0.39) 0.13 (− 0.69, 1.06) < .001 − 0.29 (− 1.26, 0.48) − 0.28 (− 1.35, 0.50) − 0.02 (− 0.72, 0.79) 0.92
 DV (cm3) − 2.10 (− 9.65, 5.06) − 2.74 (− 10.25, 3.34) 0.63 (− 6.14, 8.80) 0.002 − 1.82 (− 8.09, 3.60) − 1.89 (− 8.49, 3.84) 0.05 (− 5.75, 6.07) 0.77
Non-dense (n = 540 cases/1436 controls)
 VPD (%) − 0.11 (− 0.76, 0.66) − 0.23 (− 0.86, 0.33) 0.11 (− 0.49, 0.83) < .001 − 0.21 (− 0.85, 0.43) − 0.18 (− 0.89, 0.40) − 0.02 (− 0.60, 0.66) 0.93
 DV (cm3) − 1.28 (− 7.21, 4.98) − 1.73 (− 8.13, 3.17) 0.63 (− 4.88, 8.80) 0.002 − 1.66 (− 7.01, 3.09) − 1.58 (− 7.36, 3.17) 0.09 (− 5.59, 5.69) 0.89
Dense breast (n = 480 cases/822 controls)
 VPD (%) − 0.65 (− 2.49, 0.82) − 0.91 (− 2.52, 0.56) 0.21 (− 1.01, 1.28) 0.11 − 0.65 (− 2.33, 0.81) − 0.79 (− 2.33, 0.82) 0.00 (− 1.15, 1.13) 0.97
 DV (cm3) − 3.42 (− 13.23, 4.34) − 4.30 (− 13.59, 3.33) 0.61 (− 7.62, 8.35) 0.38 − 2.53 (− 10.01, 4.77) − 2.72 (− 10.93, 5.12) − 0.02 (− 6.16, 6.83) 0.77
  1. Control sides were defined as the same as matched cases. Determined at the time of the earliest mammogram
  2. BI-RADS Breast Imaging Reporting and Data System, VPD volumetric percent density, DV dense volume
  3. *Change was calculated by subtracting the density at the earliest mammogram from the density at the mammogram closest to diagnosis. A negative value reflects a decrease over time