High expression of NR1D1 is associated with good prognosis in triple-negative breast cancer patients treated with chemotherapy

Table 1 Characteristics of breast cancer patients and their NR1D1 expression level

Characteristics	All patients		Low NR1D1		High NR1D1
	n = 694		n = 555		n = 139
	No.	(%)	No.	(%)	No.	(%)	P value^a
Age at diagnosis (years)							0.199
≤ 50	420	60.5	343	61.8	77	55.4
> 50	274	39.5	212	38.2	62	44.6
Tumor size							0.077
T1	269	38.8	221	39.8	48	34.5
T2	378	54.5	292	56.2	86	61.9
T3 or T4	47	6.8	42	7.6	5	3.6
LN involvement							0.813
N0	354	51.0	288	51.9	66	47.5
N1	180	25.9	142	25.6	38	27.3
N2	85	12.2	67	12.1	18	12.9
N3	75	10.8	58	10.5	17	12.2
LN metastasis							0.404
Negative	354	51.0	288	51.9	66	47.5
Positive	340	49.0	267	48.1	73	52.5
AJCC stage							0.210
I	168	24.2	142	25.6	26	18.7
II	353	50.9	275	49.5	78	56.1
III	173	24.9	138	24.9	35	25.2
Histologic grade							0.011
1	76	11.0	69	12.4	7	5.0
2	246	35.4	201	36.2	45	32.4
3	323	46.5	246	44.3	77	55.4
Unknown	49	7.1	39	7.0	10	7.2
Estrogen receptor							0.021
Negative	282	40.6	213	38.4	69	49.6
Positive	411	59.2	341	61.4	70	50.4
Unknown	1	0.1	1	0.2	0	0.0
Progesterone receptor							0.393
Negative	379	54.6	298	53.7	81	58.3
Positive	314	45.2	256	46.1	58	41.7
Unknown	1	0.1	1	0.2	0	0.0
HER2 amplification							0.113
Negative	504	72.6	411	74.1	93	66.9
Positive	190	27.4	144	25.9	46	33.1
Breast cancer subtype							0.067
ER+/HER2−	334	48.1	281	50.6	53	38.1
ER+/HER2+	97	14.0	74	13.3	23	16.5
ER−/HER2+	92	13.3	69	12.4	23	16.5
TNBC (ER−/HER2−)	170	24.5	130	23.4	40	28.8
Undefined	1	0.1	1	0.2	0	0.0
Adjuvant chemotherapy							0.649
No	85	12.2	70	12.6	15	10.8
Yes	607	87.5	483	87.0	124	89.2
Unknown	2	0.3	2	0.4	0	0.0

^aChi-square test, P values less than 0.05 are considered as significant changes and marked in italics

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