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Fig. 5 | Breast Cancer Research

Fig. 5

From: Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells

Fig. 5

a Cell cycle profile of MDAMB231 cells treated with 250 nM prexasertib and/or 25 μM olaparib for 24 h. b Histogram representation of cell cycle profile in TNBC cells treated with 250 nM prexasertib and/or 25 μM olaparib for 24 h. c Mitotic catastrophe representative images in DAPI-stained nucleus of MDAMB231 cells treated with DMSO or 250 nM prexasertib or 25 μM olaparib or their combination for 24 h. d Percentage of cells with mitotic catastrophe analyzed from more than 110 cells from three different experiments is represented with standard error. Scale bar represents 5 μM (***p < 0.001 and ****p < 0.0001)

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