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Fig. 1 | Breast Cancer Research

Fig. 1

From: Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells

Fig. 1

a Expression of HR proteins in MDAMB231 cells treated with indicated concentrations of prexasertib for 24 h. b Expression of HR proteins in MDAMB231 cells treated with 250 nM prexasertib at time points indicated. c Cell cycle profile of MDAMB231 cells treated with 250 nM prexasertib for 24 h. d Histogram representation of cell cycle profile in TNBC cells treated with 250 nM prexasertib for 24 h. Error bars represent standard deviation from three independent experiments. e Representative images of MN formation in MDAMB231 cells treated with 250 nM prexasertib for 24 h. f More than 170 cells from three independent experiments were scored, and MN frequency/cell with standard error is represented in the histogram. Scale bar represents 5 μM (****p < 0.0001)

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