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Table 2 Hazard ratios (HR) for breast cancer-specific and overall mortality by the 21-gene RS

From: Adjuvant chemotherapy and survival among patients 70 years of age and younger with node-negative breast cancer and the 21-gene recurrence score of 26–30

  Breast cancer-specific mortality Overall mortality
RS 18–25
(Reference)
RS 26–30
[HR (95% CI)]
RS 18–25
(Reference)
RS 26–30
[HR (95% CI)]
2004–2015 dataset (n = 29,137)
 No. of events 249 141 754 292
 Age-adjusted model 1.00 2.17 (1.76 to 2.67) 1.00 1.43 (1.25 to 1.64)
 Age- and clinicopathological factor-adjusted model 1.00 1.81 (1.46 to 2.24) 1.00 1.32 (1.15 to 1.52)
 Age- and clinicopathological and treatment factor-adjusted model 1.00 1.81 (1.46 to 2.26) 1.00 1.37 (1.19 to 1.58)
 Continuous RS in age- and clinicopathological and treatment factor-adjusted model* 1.09 (1.06 to 1.12)/1-unit RS 1.05 (1.03 to 1.07)/1-unit RS
2010–2015 dataset (n = 19,791)
 No. of events 81 49 271 104
 Age-adjusted model 1.00 2.35 (1.65 to 3.36) 1.00 1.46 (1.16 to 1.83)
 Age- and clinicopathological factor-adjusted model 1.00 1.84 (1.27 to 2.67) 1.00 1.27 (1.01 to 1.61)
 Age- and clinicopathological and treatment factor-adjusted model 1.00 1.83 (1.25 to 2.69) 1.00 1.28 (1.00 to 1.63)
 Continuous RS in age- and clinicopathological and treatment factor-adjusted model* 1.12 (1.06 to 1.18)/1-unit RS 1.05 (1.02 to 1.08)/1-unit RS
2004–2009 dataset (n = 9346)
 No. of events 168 92 483 188
 Age-adjusted model 1.00 2.08 (1.61 to 2.68) 1.00 1.42 (1.20 to 1.68)
 Age- and clinicopathological factor-adjusted model 1.00 1.79 (1.38 to 2.33) 1.00 1.35 (1.14 to 1.61)
 Age- and clinicopathological and treatment factor-adjusted model 1.00 1.80 (1.38 to 2.36) 1.00 1.41 (1.18 to 1.69)
 Continuous RS in age- and clinicopathological and treatment factor-adjusted model* 1.07 (1.04 to 1.11)/1-unit RS 1.05 (1.03 to 1.07)/1-unit RS
  1. Age at diagnosis is used by categorization into ≤ 50, 51–60, 61–70, and > 70 years. Adjusted clinicopathological factors are year of diagnosis (2004–2005, 2006–2007, 2008–2009 in 2004–2009 dataset and 2010–2011, 2012–2013, and 2014–2015 in 2010–2015 dataset), race/ethnicity (White, Black, and other), history of cancer (no and yes), marital status (married and single/other), histologic type (ductal, lobular, and mixed ductal-lobular/other), tumor stage (T1b, T1c, and T2–3), grade (I, II, III, and missing), and ER/PR status (both ER/PR-positive and either ER/PR-positive). Treatment factors are type of surgery (breast-conservation surgery and mastectomy), radiation therapy (no/unknown and yes), and chemotherapy (no/unknown and yes)
  2. RS recurrence score, HR hazard ratio, CI confidence interval, No. number
  3. *The 21-gene RS is entered as a continuous variable into Cox’s hazard models adjusting for age at diagnosis and clinicopathological and treatment factors. HR per 1 unit increase in RS