Table 2 Hazard ratios (HR) for breast cancer-specific and overall mortality by the 21-gene RS
Breast cancer-specific mortality | Overall mortality | |||
|---|---|---|---|---|
RS 18–25 (Reference) | RS 26–30 [HR (95% CI)] | RS 18–25 (Reference) | RS 26–30 [HR (95% CI)] | |
2004–2015 dataset (n = 29,137) | ||||
No. of events | 249 | 141 | 754 | 292 |
Age-adjusted model | 1.00 | 2.17 (1.76 to 2.67) | 1.00 | 1.43 (1.25 to 1.64) |
Age- and clinicopathological factor-adjusted model | 1.00 | 1.81 (1.46 to 2.24) | 1.00 | 1.32 (1.15 to 1.52) |
Age- and clinicopathological and treatment factor-adjusted model | 1.00 | 1.81 (1.46 to 2.26) | 1.00 | 1.37 (1.19 to 1.58) |
Continuous RS in age- and clinicopathological and treatment factor-adjusted model* | 1.09 (1.06 to 1.12)/1-unit RS | 1.05 (1.03 to 1.07)/1-unit RS | ||
2010–2015 dataset (n = 19,791) | ||||
No. of events | 81 | 49 | 271 | 104 |
Age-adjusted model | 1.00 | 2.35 (1.65 to 3.36) | 1.00 | 1.46 (1.16 to 1.83) |
Age- and clinicopathological factor-adjusted model | 1.00 | 1.84 (1.27 to 2.67) | 1.00 | 1.27 (1.01 to 1.61) |
Age- and clinicopathological and treatment factor-adjusted model | 1.00 | 1.83 (1.25 to 2.69) | 1.00 | 1.28 (1.00 to 1.63) |
Continuous RS in age- and clinicopathological and treatment factor-adjusted model* | 1.12 (1.06 to 1.18)/1-unit RS | 1.05 (1.02 to 1.08)/1-unit RS | ||
2004–2009 dataset (n = 9346) | ||||
No. of events | 168 | 92 | 483 | 188 |
Age-adjusted model | 1.00 | 2.08 (1.61 to 2.68) | 1.00 | 1.42 (1.20 to 1.68) |
Age- and clinicopathological factor-adjusted model | 1.00 | 1.79 (1.38 to 2.33) | 1.00 | 1.35 (1.14 to 1.61) |
Age- and clinicopathological and treatment factor-adjusted model | 1.00 | 1.80 (1.38 to 2.36) | 1.00 | 1.41 (1.18 to 1.69) |
Continuous RS in age- and clinicopathological and treatment factor-adjusted model* | 1.07 (1.04 to 1.11)/1-unit RS | 1.05 (1.03 to 1.07)/1-unit RS | ||