Fig. 5From: Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungsGemcitabine decreases MDSCs that persist in the lungs after primary tumor resection and subsequent 4T1 growth in the lungs. a Experimental outline for (b–d); lung tissues were harvested as indicated from mice with or without 4T1 tumor resection and/or 60 mg/kg gemcitabine treatment for flow cytometry-based assessment of lung leukocytes. b Number of granulocytic-MDSCs or monocytic-MDSCs in the lungs of mice treated as in (a). Data are mean ± SEM of 7–8 mice per group. Significance compared to naïve (tumor-free) mice. c Number of macrophages in the lungs of mice treated as in (a). Data are mean ± SEM of 3–5 mice per group. d Number of eosinophils in the lungs of mice treated as in (a). Data are mean ± SEM of 3–5 mice per group. e Experimental outline for (f); lung tissues were harvested as indicated from mice with 4T1 tumor resection, gemcitabine treatment, and/or iv injection of 4T1 tumor cells prior to quantification of 4T1 cells in the lungs. f Total number of 4T1 tumor cells in the lungs of mice from (e). Data are mean ± SEM of 7–8 mice per groupBack to article page