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Fig. 2 | Breast Cancer Research

Fig. 2

From: Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs

Fig. 2

CD11b+Gr1+ cells from mice with 4T1 or 4T07 tumors, but not 67NR tumors, are immunosuppressive MDSCs. a Number of CD11b+Gr1+ cells in the lungs and spleens of mice with time after orthotopic 4T07 or 67NR mammary tumor implant. Data are mean ± SEM with 8–16 mice per time point (4T07) or 7–9 mice per time point (67NR); significance compared to time 0. b Tumor weight vs spleen weight for individual 4T07 or 67NR tumor-bearing mice. Open circle is spleen weight of n = 6 naïve mice. c CD11b+Gr1+ cells isolated from the lungs of 4T1 tumor-bearing mice suppress T cell proliferation in a concentration-dependent manner. ‘Ctrl’ bar is stimulated splenocytes alone. d CD11b+Gr1+ cells isolated from the lungs of 4T07 tumor-bearing mice suppress T cell proliferation in a concentration-dependent manner. e CD11b+Gr1+ cells isolated from the lungs of 67NR tumor-bearing mice only minimally suppress T cell proliferation. f CD11b+Gr1+ cells isolated from the lungs of naïve (tumor-free) mice are minimally suppressive. Data are mean ± SEM of triplicate wells; plots are representative of three independent experimental repeats. Significance compared to Ctrl

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