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Table 1 Clinical characteristics. The number of patients tabulated on CTC status and their clinical characteristics. The CTC status was considered positive if ≥ 5 or ≥ 1 CTCs were detected after EpCAM-dependent or EpCAM-independent enrichment, respectively. p values were calculated using the G test

From: Clonality of circulating tumor cells in breast cancer brain metastasis patients

 

≥ 5 CTCs (EpCAM dependent)

≥ 1 CTC (EpCAM independent)

Total (n)

Neg (n)

Pos (n)

p value

Total (n)

Neg (n)

Pos (n)

p value

Total

44

35

9

 

46

31

15

 

Histology

 Ductal

24

20

4

0.655

25

17

8

0.552

 Lobular

4

3

1

 

5

3

2

 

 Others

2

1

1

 

3

1

2

 

 n.a.

14

   

13

   

Age at BM

 < Mean

21

15

6

0.213

25

18

7

0.476

 > Mean

23

20

3

 

21

13

8

 

Hormone

 Neg

21

17

4

0.878

20

9

11

0.018

 Receptor

        

 Pos

19

15

4

 

21

17

4

 

 n.a.

4

   

5

   

ERBB2

 Neg

16

10

6

0.029

15

6

9

0.021

 Pos

24

22

2

 

26

20

6

 

 n.a.

4

   

5

   

Subtype

 HR-pos

8

5

3

0.102

5

3

2

0.044

 TNBC

8

5

3

 

10

3

7

 

 ERBB2-pos

24

22

2

 

26

20

6

 

 n.a.

4

   

5

   

Brain surgery

 No OP

14

10

4

0.388

15

9

6

0.471

 OP

30

25

5

 

20

22

9

 

 n.a.

0

   

11

   

Oligo brain met.

 Multiple

30

24

6

0.827

28

16

12

0.080

 Oligo

13

10

3

 

17

14

3

 

 n.a.

1

   

1

   

Bone met.

 No

25

23

2

0.021

25

18

7

0.476

 Yes

19

12

7

 

21

13

8

 

Liver met.

 No

33

28

5

0.165

31

22

9

0.471

 Yes

11

7

4

 

15

9

6

 

Pulmonary met.

 No

36

29

7

0.743

38

28

10

0.064

 Yes

8

6

2

 

8

3

5

 
  1. BM brain metastasis, OP operation, HR hormone receptor, TNBC triple-negative breast cancer, met. metastasis, n.a. data not available
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Breast Cancer Research

ISSN: 1465-542X

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