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Table 1 Clinical characteristics. The number of patients tabulated on CTC status and their clinical characteristics. The CTC status was considered positive if ≥ 5 or ≥ 1 CTCs were detected after EpCAM-dependent or EpCAM-independent enrichment, respectively. p values were calculated using the G test

From: Clonality of circulating tumor cells in breast cancer brain metastasis patients

  ≥ 5 CTCs (EpCAM dependent) ≥ 1 CTC (EpCAM independent)
Total (n) Neg (n) Pos (n) p value Total (n) Neg (n) Pos (n) p value
Total 44 35 9   46 31 15  
Histology
 Ductal 24 20 4 0.655 25 17 8 0.552
 Lobular 4 3 1   5 3 2  
 Others 2 1 1   3 1 2  
 n.a. 14     13    
Age at BM
 < Mean 21 15 6 0.213 25 18 7 0.476
 > Mean 23 20 3   21 13 8  
Hormone
 Neg 21 17 4 0.878 20 9 11 0.018
 Receptor         
 Pos 19 15 4   21 17 4  
 n.a. 4     5    
ERBB2
 Neg 16 10 6 0.029 15 6 9 0.021
 Pos 24 22 2   26 20 6  
 n.a. 4     5    
Subtype
 HR-pos 8 5 3 0.102 5 3 2 0.044
 TNBC 8 5 3   10 3 7  
 ERBB2-pos 24 22 2   26 20 6  
 n.a. 4     5    
Brain surgery
 No OP 14 10 4 0.388 15 9 6 0.471
 OP 30 25 5   20 22 9  
 n.a. 0     11    
Oligo brain met.
 Multiple 30 24 6 0.827 28 16 12 0.080
 Oligo 13 10 3   17 14 3  
 n.a. 1     1    
Bone met.
 No 25 23 2 0.021 25 18 7 0.476
 Yes 19 12 7   21 13 8  
Liver met.
 No 33 28 5 0.165 31 22 9 0.471
 Yes 11 7 4   15 9 6  
Pulmonary met.
 No 36 29 7 0.743 38 28 10 0.064
 Yes 8 6 2   8 3 5  
  1. BM brain metastasis, OP operation, HR hormone receptor, TNBC triple-negative breast cancer, met. metastasis, n.a. data not available