Fig. 2

Overall trajectories of other diseases among breast cancer patients. This figure illustrates an overview of disease trajectories identified in our analysis. The combined ICD-10 codes for the diseases are shown within the circle. The color of the circle represents the hazard ratio of this disease among the breast cancer patients, compared to matched individuals. The width of the arrow connecting two circles corresponds to the number of breast cancer patients with this disease trajectory. The color of the arrows indicates the odds ratio of the sequential association between the two diseases. The strongest association in this figure is C00 → K56, suggesting a 15 times increased risk of ileus after other cancer diagnosis, with 83 patients in the cohort experiencing this trajectory. Trajectories starting with M15 and M20 were not included, given their low HR (HR ≤ 1.1) and that they were probably the result of surveillance bias