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Table 2 Short-term and long-term outcome

From: Addition of zoledronic acid to neoadjuvant chemotherapy is not beneficial in patients with HER2-negative stage II/III breast cancer: 5-year survival analysis of the NEOZOTAC trial (BOOG 2010-01)

Response

TAC + ZA

N = 122 (49.6%)

TAC

N = 124 (50.4%)

P value

pCR breast and LN

 Yes

16 (13.3%)

16 (13.2%)

 

 No

104 (86.7%)

105 (86.8%)

0.980

Miller and Payne

 1

19 (15.8%)

18 (14.8%)

 

 2

35 (29.2%)

31 (25.4%)

 

 3

24 (20.0%)

25 (20.5%)

 

 4

21 (17.5%)

25 (20.5%)

 

 5

21 (17.5%)

23 (18.9%)

0.950

Recurrence

 Total

29 (23.8%)

20 (16.1%)

0.134

 Local

5 (4.1%)

5 (4.0%)

0.979

 Regional

7 (5.7%)

4 (3.2%)

0.341

 Distant

27 (22.1%)

17 (13.7%)

0.085

 Second primary tumor

5 (4.1%)

5 (4.0%)

0.979

Death

 Yes

23 (18.9%)

11 (8.9%)

 

 No

99 (81.1%)

113 (91.1%)

0.023

Cause of death

 Breast cancer

22 (95.7%)

11 (91.6%)

0.630

 Other

1 (4.3%)

1 (8.3%)

 
  1. TAC docetaxel, doxorubicin, and cyclophosphamide, ZA zoledronic acid, pCR pathologic complete response, LN lymph nodes, MP Miller and Payne
  2. the italicized data have a significance of > 0.05