Fig. 1

Antitumour activity (a) and duration on treatment (b) for patients in the recommended dose cohorts for each arm. Partial regression of brain metastases in a 53-year-old patient after 59 days of treatment with epertinib 400 mg in combination with trastuzumab plus capecitabine in arm C (c). Brain metastases first appeared during prior treatment with trastuzumab with capecitabine, and the patient underwent whole-brain radiotherapy followed by T-DM1. After further progression in the brain the patient was enrolled in this study. T: trastuzumab, L: lapatinib, K: T-DM1, P: pertuzumab, V: vinorelbine, C: capecitabine, BM: brain metastases