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Fig. 1 | Breast Cancer Research

Fig. 1

From: Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2+ve breast cancer metastasis

Fig. 1

TBCP-1 cells are phenotypically and functionally similar to HER2+ve breast cancer. a Representative western blots (left panel) and quantitation (right panels) of ERα, PR and HER2 protein expression. Data in the right panels show relative protein expression normalised to GAPDH and are expressed as mean ± SD of three independent experiments (n = 3). 67NR cells were used as a positive control for ER and PR, and 4T1Br4 used as a negative control for all three receptors. ***p < 0.001. TBCP-1 cell proliferation in the presence of b lapatinib or c 4-hydroxytamoxifen was measured over 5 days in a standard SRB proliferation assay. SKBR3 and MCF7 were used as HER2- or ER-positive controls, respectively. Each point on the curves represents the mean ± SD of three independent experiments (n = 3). *p < 0.05, ****p < 0.0001

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