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Fig. 6 | Breast Cancer Research

Fig. 6

From: Dynamically decreased miR-671-5p expression is associated with oncogenic transformation and radiochemoresistance in breast cancer

Fig. 6

miR-671-5p sensitizes the 21T series cell lines to UVC exposure and chemotherapeutic agents by alleviating DNA repair capability. a The sensitivity of UV exposure and drug treatment was measured by MTT assay. The 21T cells were transfected with mock, miR-671-5p mimic, inhibitor mock, and miR-671-5p inhibitor. Cells were treated with UVC and chemotherapeutic agents 48 h after transfection. MTT was added, and absorbance was measured at different time points. miR-671-5p overexpression significantly increased sensitivity of 21T cells to UV, cisplatin, paclitaxel, and epirubicin but not to 5-Fu compared to the mock-transfected one. b HCR assay was performed to quantitatively measure DNA repair capability in 21T cells. Results are displayed as mean data ± SE. **p < 0.01, *p < 0.05

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