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Table 2 Multivariable fractional polynomial functions and logarithm hazard ratios for breast cancer-specific survival using all variables

From: Development of a prediction model for breast cancer based on the national cancer registry in Taiwan

Variables Function logHR P value
Continuous variables
 Age1 (age/100)−0.5 − 10.87 0.0035
 Age2 (age/100)−0.5 × log(age/100) 8.968 < 0.001
 Tumor size, mm log(size/10) 0.7678 < 0.001
 Node-positive ratio ((ratio + 0.1)/0.1)0.5 0.5339 < 0.001
Categorical variables
 Chemotherapy
  Without
  With − 0.4147 < 0.001
 Radiotherapy
  Without
  With − 0.3203 < 0.001
 Grade
  1
  2 0.4795 0.015
  3 0.818 < 0.001
 Subtype
  Luminal-like
  HER2 0.1806 0.22
  Triple negative 0.6457 < 0.001
 Pathological stage
  1
  2 0.5311 < 0.001
  3 1.134 < 0.001
  4 2.172 < 0.001
 Targeted therapy
  Without
  With − 0.4687 0.001
 Hormone/steroid therapy
  Without
  With − 0.8397 < 0.001
 Lymph vessel or vascular invasion (LVI)
  No
  Yes 0.3321 < 0.001
  1. Derived from model 2