Table 1 Distribution of patient and tumor characteristics in relation to nuclear VDR expression
From: Vitamin D receptor expression in invasive breast tumors and breast cancer survival
Eligible cases | All n = 912 | ||||||
|---|---|---|---|---|---|---|---|
Tumor in tissue microarray n (%) | Yes 718 (78.7) | No 194 (21.3) | |||||
Nuclear VDR assessable n (%) | Yes 678 (94.4) | No 40 (5.6) | |||||
Nuclear VDR fraction n (%) | Negative 0–10% 125 (18.4) | Positive 11–50% 437 (64.5) | Positive 51–100% 116 (17.1) | ||||
Factor | n (%) or mean (SD) | n (%) or mean (SD) | n (%) or mean (SD) | n (%) or mean (SD) | p value* | n (%) or mean (SD) | n (%) or mean (SD) |
Age at baseline | 56.4 (7.2) | 55.4 (7.1) | 56.6 (7.1) | 55.7 (7.4) | 0.109** | 53.9 (7.5) | 57.6 (7.0) |
Age at diagnosis | 65.4 (8.1) | 64.1 (7.7) | 66.0 (7.8) | 64.8 (8.6) | 0.026** | 62.1 (9.1) | 65.9 (8.3) |
Season of diagnosis | |||||||
Winter | 241 (26.4) | 35 (28.0) | 116 (26.5) | 29 (25.0) | 0.646 | 13 (32.5) | 48 (24.7) |
Spring | 221 (24.2) | 38 (30.4) | 97 (22.2) | 27 (23.3) | 9 (22.5) | 50 (25.8) | |
Summer | 187 (20.5) | 19 (15.2) | 96 (22.0) | 23 (19.8) | 6 (15.0) | 43 (22.2) | |
Fall | 263 (28.8) | 33 (26.4) | 128 (29.3) | 37 (31.9) | 12 (30.0) | 53 (27.3) | |
BMI at baseline | |||||||
< 25 | 467 (51.2) | 60 (48.0) | 215 (49.2) | 70 (60.3) | 0.253 | 24 (60) | 98 (50.5) |
≥ 25–30 | 310 (34) | 45 (36.0) | 150 (34.3) | 33 (28.4) | 11 (27.5) | 71 (36.6) | |
≥ 30 | 135 (14.8) | 20 (16.0) | 72 (16.5) | 13 (11.2) | 5 (12.5) | 25 (12.9) | |
Tumor size | |||||||
1–10 mm | 229 (25.8) | 14 (11.2) | 93 (21.4) | 33 (28.7) | 0.002 | 20 (50) | 69 (39.7) |
11–20 mm | 409 (46.1) | 57 (45.6) | 217 (49.9) | 51 (44.3) | 13 (32.5) | 71 (40.8) | |
≥ 21 mm | 250 (28.2) | 54 (43.2) | 125 (28.7) | 31 (27.0) | 6 (15.0) | 34 (19.5) | |
Unknown | 24 | 0 | 2 | 1 | 1 | 20 | |
Lymph node status | |||||||
Positive | 262 (31.9) | 50 (41.0) | 135 (32.8) | 36 (32.4) | 0.226 | 9 (22.5) | 32 (22.7) |
Negative | 559 (68.1) | 72 (59.0) | 276 (67.2) | 75 (67.6) | 27 (67.5) | 109 (77.3) | |
Unknown | 91 | 3 | 26 | 5 | 4 | 53 | |
Nottingham grade | |||||||
I | 227 (27.2) | 7 (5.9) | 119 (27.7) | 42 (36.5) | < 0.001 | 12 (30.0) | 47 (34.8) |
II | 393 (47.0) | 35 (29.4) | 219 (50.9) | 61 (53.0) | 16 (40.0) | 62 (45.9) | |
III | 216 (25.8) | 77 (64.7) | 92 (21.4) | 12 (10.4) | 9 (22.5) | 26 (19.3) | |
Unknown | 76 | 6 | 7 | 1 | 3 | 59 | |
Histological type | |||||||
Ductal | 596 (70.9) | 103 (85.1) | 290 (67.8) | 84 (72.4) | < 0.001 | 24 (60.0) | 95 (68.3) |
Lobular | 166 (19.7) | 7 (5.8) | 113 (26.4) | 20 (17.2) | 7 (17.5) | 19 (13.7) | |
Other/mixed | 79 (9.4) | 11 (9.1) | 25 (5.8) | 12 (10.3) | 6 (15.0) | 25 (18.0) | |
Unknown | 71 | 4 | 9 | 0 | 3 | 55 | |
ER status | |||||||
Neg (0–10%) | 84 (10.8) | 45 (39.5) | 25 (6.1) | 4 (3.6) | < 0.001 | 3 (7.5) | 7 (6.0) |
Pos (> 10%) | 694 (89.2) | 69 (60.5) | 382 (93.9) | 106 (96.4) | 28 (70.0) | 109 (94.0) | |
Unknown | 134 | 11 | 30 | 6 | 9 | 78 | |
PgR status | |||||||
Neg (0–10%) | 311 (41.7) | 75 (67.0) | 135 (34.5) | 39 (36.8) | < 0.001 | 14 (35.0) | 48 (44.9) |
Pos (> 10%) | 435 (58.3) | 37 (33.0) | 256 (65.5) | 67 (63.2) | 16 (40.0) | 59 (55.1) | |
Unknown | 166 | 13 | 46 | 10 | 10 | 87 | |
HER2 | |||||||
Neg | 646 (90.9) | 102 (91.1) | 335 (90.3) | 91 (91) | 0.957 | 26 (65.0) | 92 (92.0) |
Pos | 65 (9.1) | 10 (8.9) | 36 (9.7) | 9 (9.0) | 2 (5.0) | 8 (8.0) | |
Unknown | 201 | 13 | 66 | 16 | 12 | 94 | |
Ki67 | |||||||
Low | 258 (40.6) | 16 (15.8) | 150 (45.9) | 43 (45.7) | < 0.001 | 9 (22.5) | 40 (44.4) |
Intermediate | 198 (31.2) | 28 (27.7) | 104 (31.8) | 36 (38.3) | 5 (12.5) | 25 (27.8) | |
High | 179 (28.2) | 57 (56.4) | 73 (22.3) | 15 (16.0) | 9 (22.5) | 25 (27.8) | |
Unknown | 277 | 24 | 110 | 22 | 17 | 104 | |
Molecular subtypes | |||||||
Luminal A-like | 350 (55.6) | 19 (18.6) | 207 (63.1) | 62 (66.7) | < 0.001 | 11 (27.5) | 51 (62.2) |
Luminal B-like | 158 (25.1) | 33 (32.4) | 76 (23.2) | 20 (21.5) | 8 (20.0) | 21 (25.6) | |
HER2 positive | 65 (10.3) | 10 (9.8) | 36 (11.0) | 9 (9.7) | 2 (5.0) | 8 (9.8) | |
Triple negative | 56 (8.9) | 40 (39.2) | 9 (2.7) | 2 (2.2) | 3 (7.5) | 2 (2.4) | |
Unknown | 283 | 23 | 109 | 23 | 16 | 112 | |