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Fig. 7 | Breast Cancer Research

Fig. 7

From: Vasculogenic mimicry is associated with trastuzumab resistance of HER2-positive breast cancer

Fig. 7

Salinomycin strongly inhibited VM in Tzm-resistant HER2+ breast cancer cells. a Percentages of tube formation for three Tzm-resistant cell lines (SKBR3-TR, JIMT-1, and MDA-MB-361) in the presence of 9 small molecule inhibitors compared with that in DMSO controls. The color key indicates the percentage of tube formation. b Tube formation assay for Tzm-resistant cell lines and HUVECs cultured on Matrigel in the presence of 0, 1 or 4 μM salinomycin for up to 72 h. The numbers of tubes formed are shown (n = 3; mean ± SD). ns., not significant; *P < 0.05; **P < 0.01. c Representative photographs showing tube formation in Tzm-resistant cell lines and HUVECs. Scale bar, 0.5 mm. d Time-lapse microscopy of tube formation in MDA-MB-361 cells in the presence or absence of 4 μM salinomycin. Scale bar, 0.5 mm

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