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Fig. 1 | Breast Cancer Research

Fig. 1

From: The prognostic value of JUNB-positive CTCs in metastatic breast cancer: from bioinformatics to phenotypic characterization

Fig. 1

Bioinformatics and functional enrichment analysis for biomarker discovery. Twenty-four genes were obtained from a data-driven computational procedure (data integration, cross-site comparisons) and were further explored by using functional enrichment analysis. CXCR4 plays a central role in this analysis. Based on four databases (G2SBC, WebGestalt, GSEA, and KEGG), significant biological information was validated and five genes of the 24-signature were prioritized according to their direct or indirect association with the CXCR4 pathway. These six molecules (CXCR4, JUNB, YWHAB, TYROBP, NFYA, and PRDX1) were experimentally evaluated in biological samples

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