Fig. 1From: The prognostic value of JUNB-positive CTCs in metastatic breast cancer: from bioinformatics to phenotypic characterizationBioinformatics and functional enrichment analysis for biomarker discovery. Twenty-four genes were obtained from a data-driven computational procedure (data integration, cross-site comparisons) and were further explored by using functional enrichment analysis. CXCR4 plays a central role in this analysis. Based on four databases (G2SBC, WebGestalt, GSEA, and KEGG), significant biological information was validated and five genes of the 24-signature were prioritized according to their direct or indirect association with the CXCR4 pathway. These six molecules (CXCR4, JUNB, YWHAB, TYROBP, NFYA, and PRDX1) were experimentally evaluated in biological samplesBack to article page