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Fig. 7 | Breast Cancer Research

Fig. 7

From: Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer

Fig. 7

Mouse LP cells harbor gene enrichment for estrogen signaling pathway and Notch signaling pathway. a Heatmap showing differential gene expression in mouse mammary LP cells. b GSEA querying hallmark genes (h.all.v6.0.symbols.gmt) in mouse mammary LP cells, depicting significant enrichment of c estrogen early response genes (HALLMARK_ESTROGEN_RESPONSE_EARLY), d estrogen late response genes (HALLMARK_ESTROGEN_RESPONSE_LATE), and e Notch signaling pathway genes (HALLMARK_NOTCH_SIGNALING_ PATHWAY). f GSEA querying genes consistently up- or downregulated in sorted mammary epithelial cell compartments, showing significant enrichment of g genes upregulated in mammary luminal progenitor cells (LIM_MAMMARY_LUMINAL_PROGENITOR_UP) in mouse mammary LP cells isolated from the AI glands when compared to the LP cells from the GI gland. NES normalized enrichment score, FDR false discovery rate, MaSC mammary stem cell, ML mature luminal

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