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Fig. 6 | Breast Cancer Research

Fig. 6

From: Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer

Fig. 6

Abrupt involution expands the luminal progenitor cell population and disrupts the epithelial cell hierarchy. FACS analysis of CD24 and CD29 expression in lineage-negative population of the mammary gland (left panel) and CD24 and CD61 expression in the luminal cell population (right panel) in a GI and b AI mammary gland. c Pie chart showing distribution of mammary epithelial subpopulation in 6-week-old virgin mice and 10-week-old nulliparous mice, on lactating day 7 (d7), and on postpartum day 21, day 28, day 56, and day 120 as indicated in the GI and AI cohort. Mammary glands from 6- and 10-week-old virgin mice were used as controls. ML mature luminal cells, LP luminal progenitor cells, MaSC mammary stem cell-enriched population

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