Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy

Table 7 Age- and BMI-adjusted¹ linear regression estimates for the relation of IGF factors (in quintiles) with mammographic density measures

	% MD-V¹		% MD-A		Absolute MD-V		Absolute MD-A		Non-dense volume		Non-dense area
	β	p ³	β	p	β	p	β	p	β	p	β	p
Premenopausal women
Factor 1²	− 0.13	0.08	− 0.18	0.05	0.01	0.97	− 0.13	0.27	0.40	0.19	0.16	0.23
Factor 2	− 0.05	0.49	− 0.04	0.65	− 0.11	0.53	− 0.73	0.50	0.07	0.80	− 0.04	0.74
Postmenopausal women
Factor 1	− 0.19	0.02	0.09	0.43	− 0.09	0.67	0.20	0.17	0.91	0.04	− 0.01	0.93
Factor 2	− 0.03	0.73	− 0.66	0.55	0.02	0.94	− 0.07	0.61	0.06	0.98	0.09	0.59

MD-V mammographic density-volume, MD-A MD-area
¹All models were adjusted for age, BMI, and BMI² in the model. Excluded women with BMI > 45
²Factor 1 was positively correlated with IGF-I and IGFBP-3 and inversely correlated with IGFBP-1 and IGFBP-2; factor 2 was positively correlated with IGFBP-4, IGFBP-5, and IGFBP-7. Quintiles’ cutpoints for factor 1 and factor 2 were created based on their distributions in premenopausal and postmenopausal women separately
³p values < 0.05 are in italics

ISSN: 1465-542X