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Table 7 Age- and BMI-adjusted1 linear regression estimates for the relation of IGF factors (in quintiles) with mammographic density measures

From: Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy

  % MD-V1 % MD-A Absolute MD-V Absolute MD-A Non-dense volume Non-dense area
β p 3 β p β p β p β p β p
Premenopausal women             
 Factor 12 − 0.13 0.08 − 0.18 0.05 0.01 0.97 − 0.13 0.27 0.40 0.19 0.16 0.23
 Factor 2 − 0.05 0.49 − 0.04 0.65 − 0.11 0.53 − 0.73 0.50 0.07 0.80 − 0.04 0.74
Postmenopausal women
 Factor 1 − 0.19 0.02 0.09 0.43 − 0.09 0.67 0.20 0.17 0.91 0.04 − 0.01 0.93
 Factor 2 − 0.03 0.73 − 0.66 0.55 0.02 0.94 − 0.07 0.61 0.06 0.98 0.09 0.59
  1. MD-V mammographic density-volume, MD-A MD-area
  2. 1All models were adjusted for age, BMI, and BMI2 in the model. Excluded women with BMI > 45
  3. 2Factor 1 was positively correlated with IGF-I and IGFBP-3 and inversely correlated with IGFBP-1 and IGFBP-2; factor 2 was positively correlated with IGFBP-4, IGFBP-5, and IGFBP-7. Quintiles’ cutpoints for factor 1 and factor 2 were created based on their distributions in premenopausal and postmenopausal women separately
  4. 3p values < 0.05 are in italics