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Table 5 Age- and BMI-adjusted linear2 regression estimates for associations between IGF measures (pg/mL) and mammographic density measures, postmenopausal women (N = 101)

From: Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy

IGF measures % MD-V1 % MD-A Absolute MD-V Absolute MD-A Non-Dense Volume Non-Dense Area
β p 4 β p β p β p β p β p
IGF-I − 0.55 0.89 1.97 0.70 − 6.57 0.49 3.10 0.64 − 5.95 0.77 − 5.26 0.48
IGFBP-13 50.06 0.15 − 49.56 0.28 − 84.48 0.34 − 77.58 0.20 − 418.94 0.02 − 8.09 0.91
IGFBP-2 2.04 0.003 − 0.01 0.99 − 1.29 0.47 − 0.89 0.47 − 13.13 0.0003 − 1.33 0.33
IGFBP-3 − 0.13 0.37 0.21 0.28 − 0.51 0.16 0.32 0.20 0.06 0.93 − 0.26 0.36
IGFBP-4 − 1.72 0.55 − 2.22 0.56 2.74 0.70 − 1.03 0.84 12.02 0.43 8.42 0.13
IGFBP-5 − 0.74 0.53 − 0.10 0.95 − 0.36 0.91 0.80 0.70 2.67 0.67 − 0.29 0.90
IGFBP-6 − 3.08 0.21 − 4.67 0.15 2.20 0.72 − 3.89 0.37 26.46 0.04 11.89 0.01
IGFBP-7 3.56 0.53 − 5.21 0.49 14.32 0.32 − 9.46 0.34 − 1.77 0.95 8.43 0.45
IGF-I:IGFBP-1 < − 0.001 0.04 < 0.001 0.70 < − 0.001 0.85 < 0.001 0.33 0.0002 0.03 < 0.001 0.75
IGF-I:IGFBP-2 − 0.16 0.06 0.12 0.30 − 0.08 0.72 0.22 0.16 0.88 0.06 − 0.03 0.86
IGF-I:IGFBP-3 3.07 0.53 − 5.59 0.39 4.70 0.70 − 8.64 0.31 − 13.09 0.61 0.61 0.95
IGF-I:IGFBP-4 0.01 0.96 0.14 0.41 − 0.14 0.67 0.19 0.38 − 0.11 0.87 − 0.25 0.31
IGF-I:IGFBP-5 0.12 0.71 0.24 0.57 − 0.15 0.86 0.26 0.65 − 0.58 0.73 − 0.23 0.71
IGF-I:IGFBP-6 0.11 0.44 0.19 0.32 − 0.32 0.38 0.16 0.53 − 1.26 0.10 − 0.62 0.03
IGF-I:IGFBP-7 − 0.07 0.54 0.11 0.45 − 0.20 0.45 0.22 0.24 0.11 0.84 − 0.11 0.59
IGF-I:Total IGFBP 0.72 0.91 − 2.95 0.72 1.37 0.93 − 4.15 0.71 − 4.38 0.90 − 2.71 0.83
  1. IGF insulin-like growth factor, IGFBP IGF binding protein, MD-V mammographic density-volume, MD-A MD-area
  2. 1Mammographic density measures were square-root transformed
  3. 2All models were adjusted for age, BMI, and BMI2 in the model. Excluded women with BMI > 45 (N=2)
  4. 3For IGFBP-1, N = 91 samples were below the lower limit of detection (LLOD) and were reassigned as ½ LLOD (0.025)
  5. 4p values < 0.05 are in italics