Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy

Table 5 Age- and BMI-adjusted linear² regression estimates for associations between IGF measures (pg/mL) and mammographic density measures, postmenopausal women (N = 101)

IGF measures	% MD-V¹		% MD-A		Absolute MD-V		Absolute MD-A		Non-Dense Volume		Non-Dense Area
IGF measures	β	p ⁴	β	p	β	p	β	p	β	p	β	p
IGF-I	− 0.55	0.89	1.97	0.70	− 6.57	0.49	3.10	0.64	− 5.95	0.77	− 5.26	0.48
IGFBP-1³	50.06	0.15	− 49.56	0.28	− 84.48	0.34	− 77.58	0.20	− 418.94	0.02	− 8.09	0.91
IGFBP-2	2.04	0.003	− 0.01	0.99	− 1.29	0.47	− 0.89	0.47	− 13.13	0.0003	− 1.33	0.33
IGFBP-3	− 0.13	0.37	0.21	0.28	− 0.51	0.16	0.32	0.20	0.06	0.93	− 0.26	0.36
IGFBP-4	− 1.72	0.55	− 2.22	0.56	2.74	0.70	− 1.03	0.84	12.02	0.43	8.42	0.13
IGFBP-5	− 0.74	0.53	− 0.10	0.95	− 0.36	0.91	0.80	0.70	2.67	0.67	− 0.29	0.90
IGFBP-6	− 3.08	0.21	− 4.67	0.15	2.20	0.72	− 3.89	0.37	26.46	0.04	11.89	0.01
IGFBP-7	3.56	0.53	− 5.21	0.49	14.32	0.32	− 9.46	0.34	− 1.77	0.95	8.43	0.45
IGF-I:IGFBP-1	< − 0.001	0.04	< 0.001	0.70	< − 0.001	0.85	< 0.001	0.33	0.0002	0.03	< 0.001	0.75
IGF-I:IGFBP-2	− 0.16	0.06	0.12	0.30	− 0.08	0.72	0.22	0.16	0.88	0.06	− 0.03	0.86
IGF-I:IGFBP-3	3.07	0.53	− 5.59	0.39	4.70	0.70	− 8.64	0.31	− 13.09	0.61	0.61	0.95
IGF-I:IGFBP-4	0.01	0.96	0.14	0.41	− 0.14	0.67	0.19	0.38	− 0.11	0.87	− 0.25	0.31
IGF-I:IGFBP-5	0.12	0.71	0.24	0.57	− 0.15	0.86	0.26	0.65	− 0.58	0.73	− 0.23	0.71
IGF-I:IGFBP-6	0.11	0.44	0.19	0.32	− 0.32	0.38	0.16	0.53	− 1.26	0.10	− 0.62	0.03
IGF-I:IGFBP-7	− 0.07	0.54	0.11	0.45	− 0.20	0.45	0.22	0.24	0.11	0.84	− 0.11	0.59
IGF-I:Total IGFBP	0.72	0.91	− 2.95	0.72	1.37	0.93	− 4.15	0.71	− 4.38	0.90	− 2.71	0.83

IGF insulin-like growth factor, IGFBP IGF binding protein, MD-V mammographic density-volume, MD-A MD-area
¹Mammographic density measures were square-root transformed
²All models were adjusted for age, BMI, and BMI² in the model. Excluded women with BMI > 45 (N=2)
³For IGFBP-1, N = 91 samples were below the lower limit of detection (LLOD) and were reassigned as ½ LLOD (0.025)
⁴p values < 0.05 are in italics

ISSN: 1465-542X