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Table 4 Age- and BMI-adjusted2 linear regression estimates for associations between IGF measures (pg/mL) and mammographic density measures, premenopausal women (N = 189)

From: Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy

IGF measures % MD-V1 % MD-A Absolute MD-V Absolute MD-A Non-dense volume Non-dense area
β p 4 β p β p β p β p β p
IGF-I 0.11 0.97 − 1.29 0.69 − 0.39 0.95 − 0.42 0.92 − 10.33 0.33 − 1.99 0.65
IGFBP-13 17.19 0.51 21.93 0.51 − 5.38 0.94 18.15 0.66 − 133.91 0.22 − 34.22 0.46
IGFBP-2 1.49 0.02 1.55 0.05 0.35 0.83 1.48 0.13 − 6.56 0.01 − 1.74 0.11
IGFBP-3 − 0.20 0.15 − 0.34 0.05 0.03 0.93 − 0.24 0.28 0.57 0.33 0.33 0.18
IGFBP-4 − 7.19 0.01 − 5.08 0.18 − 5.55 0.46 − 4.13 0.38 25.06 0.04 5.09 0.33
IGFBP-5 − 0.50 0.50 0.37 0.69 − 0.37 0.84 0.45 0.70 0.48 0.88 − 1.21 0.35
IGFBP-6 0.89 0.71 2.37 0.44 9.34 0.12 5.26 0.17 1.73 0.86 0.34 0.94
IGFBP-7 − 0.80 0.83 − 0.89 0.85 − 3.52 0.71 − 2.59 0.66 − 0.90 0.95 − 1.59 0.81
IGF-I:IGFBP-1 < 0.001 0.91 < − 0.001 0.62 < − 0.001 0.67 < − 0.001 0.43 < − 0.001 0.61 < − 0.001 0.71
IGF-I:IGFBP-2 − 0.17 0.07 − 0.20 0.10 −0.17 0.47 −0.19 0.21 0.39 0.33 0.10 0.56
IGF-I:IGFBP-3 3.31 0.28 3.29 0.40 0.003 0.99 3.27 0.50 − 22.38 0.08 − 7.38 0.17
IGF-I:IGFBP-4 0.05 0.46 − 0.03 0.73 0.05 0.80 − 0.01 0.92 − 0.40 0.18 − 0.04 0.74
IGF-I:IGFBP-5 − 0.02 0.93 − 0.32 0.25 0.01 0.99 − 0.23 0.51 − 0.37 0.69 0.36 0.36
IGF-I:IGFBP-6 − 0.03 0.83 − 0.19 0.29 − 0.37 0.29 − 0.27 0.23 − 0.64 0.28 − 0.11 0.64
IGF-I:IGFBP-7 − 0.04 0.54 − 0.07 0.41 − 0.05 0.78 − 0.04 0.70 − 0.08 0.76 0.01 0.93
IGF-I:Total IGFBP 2.99 0.46 1.35 0.80 0.20 0.98 1.76 0.78 − 24.14 0.16 − 6.35 0.37
  1. IGF insulin-like growth factor, IGFBP IGF binding protein, MD-V mammographic density-volume, MD-A MD-area
  2. 1Mammographic density measures were square-root transformed
  3. 2All models were adjusted for age, BMI, and BMI2 in the model. Excluded women with BMI > 45 (N=4)
  4. 3For IGFBP-1, N = 91 samples were below the lower limit of detection (LLOD) and were reassigned as ½ LLOD (0.025)
  5. 4p values < 0.05 are in italics