Table 2 Relationship of circulating unadjusted geometric mean concentrations of IGF-I and IGFP-1–7 (ng/mL) with select participant characteristics in premenopausal women
Characteristics | N | IGF-I | IGFBP-1 | IGFBP-2 | IGFBP-3 | IGFBP-4 | IGFBP-5 | IGFBP-6 | IGFBP-7 |
Mean1 (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | ||
Age at biopsy (years) | |||||||||
< 45 | 56 | 131 (121–142) | 1.08 (0.46–1.71) | 340 (298–381) | 3499 (3321–3678) | 135 (126–143) | 402 (378–425) | 178 (167–189) | 105 (100–110) |
45–49 | 83 | 123 (114–131) | 0.78 (0.40–1.17) | 344 (311–378) | 3393 (3243–3542) | 130 (123–137) | 390 (366–414) | 185 (178–193) | 107 (102–111) |
≥ 50 | 54 | 112 (104–120) | 0.60 (0.21–0.99) | 308 (263–354) | 3511 (3328–3694) | 128 (121–135) | 363 (338–388) | 199 (187–210) | 111 (105–117) |
p trend (p het) | 0.005 (0.02) | 0.18 (0.88) | 0.30 (0.4) | 0.94 (0.53) | 0.25 (0.50) | 0.04 (0.11) | 0.009 (0.03) | 0.15 (0.31) | |
Education | |||||||||
≤ High school grad/GED | 27 | 107 (94–121) | 3.69 (2.46-4.92) | 326 (264–388) | 3509 (3198–3820) | 132 (120–144) | 336 (307–365) | 191 (178–205) | 106 (96–115) |
Some college/tech school | 37 | 122 (109–135) | 2.42 (1.66-3.18) | 277 (231–323) | 3483 (3245–3721) | 129 (120–138) | 376 (351–401) | 191 (181–201) | 101 (95–107) |
≥ College graduate | 129 | 125 (119–131) | 3.42 (2.95-3.88) | 352 (324–380) | 3438 (3326–3549) | 131 (126–137) | 400 (381–419) | 185 (177–192) | 110 (106–113) |
p trend (p het) | 0.02 (0.05) | 0.77 (0.11) | 0.11 (0.03) | 0.58 (0.86) | 0.96 (0.89) | 0.001 (0.005) | 0.37 (0.62) | 0.12 (0.05) | |
Body mass index (kg/m2) | |||||||||
< 25 | 97 | 124 (117–131) | 2.06 (1.34–2.79) | 399 (364–433) | 3343 (3200–3485) | 128 (121–134) | 396 (375–418) | 185 (177–192) | 107 (103–112) |
25.0–29.9 | 48 | 122 (111–133) | 0.91 (0.35–1.48) | 340 (297–383) | 3483 (3292–3675) | 133 (125–141) | 380 (357–404) | 189 (177–201) | 107 (102–113) |
≥ 30 | 48 | 118 (107–128) | 0.10 (0.04–0.16) | 225 (200–250) | 3670 (3506–3833) | 136 (127–145) | 370 (342–398) | 189 (176–201) | 108 (102–113) |
p trend (p het) | 0.31 (0.59) | < 0.0001 (< 0.0001) | < 0.0001 (< 0.0001) | 0.007 (0.03) | 0.11 (0.27) | 0.12 (0.29) | 0.53 (0.76) | 0.98 (0.99) | |
Age at menarche (years) | |||||||||
≤ 12 | 69 | 122 (112–131) | 0.79 (0.38–1.21) | 320 (283–358) | 3561 (3394–3728) | 136 (129–144) | 381 (351–411) | 187 (177–197) | 113 (107–119) |
13 | 73 | 122 (114–130) | 0.99 (0.47–1.51) | 343 (304–382) | 3449 (3287–3611) | 129 (123–136) | 387 (367–401) | 184 (175–193) | 106 (102–110) |
≥ 14 | 48 | 123 (114–132) | 0.58 (0.19–0.97) | 335 (290–380) | 3342 (3162–3522) | 128 (119–136) | 394 (373–415) | 191 (179–203) | 104 (98–110) |
p trend (p het) | 0.83 (0.97) | 0.55 (0.71) | 0.58 (0.67) | 0.09 (0.23) | 0.12 (0.25) | 0.49 (0.78) | 0.71 (0.65) | 0.02 (0.05) | |
Age at first birth (years) | |||||||||
Nulliparous/ ≥ 30 years | 94 | 118 (111–126) | 0.83 (0.44–1.22) | 338 (302–373) | 3324 (3188–3461) | 132 (125–139) | 392 (370–414) | 184 (176–192) | 108 (104–113) |
< 30 years | 98 | 126 (119–133) | 0.77 (0.42–1.12) | 329 (299–359) | 3593 (3459–3727) | 130 (124–135) | 379 (361–398) | 191 (183–199) | 107 (103–111) |
p het | 0.14 | 0.81 | 0.70 | 0.007 | 0.60 | 0.39 | 0.22 | 0.61 | |
Parity | |||||||||
Nulliparous (0) | 45 | 111 (100–122) | 0.55 (0.15–0.96) | 329 (274–383) | 3251 (3052–3450) | 130 (121–139) | 378 (350–407) | 179 (168–191) | 102 (97–106) |
1 | 20 | 122 (108–135) | 0.51 (0.003–1.02) | 272 (220–325) | 3414 (3124–3704) | 136 (119–154) | 394 (328–460) | 180 (165–197) | 116 (101–132) |
2 | 82 | 127 (119–134) | 0.81 (0.41–1.21) | 344 (309–378) | 3528 (3388–3667) | 128 (121–135) | 390 (370–409) | 190 (182–199) | 109 (105–114) |
≥ 3 | 46 | 126 (115–137) | 1.36 (0.54–2.18) | 346 (300–391) | 3557 (3340–3774) | 135 (127–142) | 382 (354–411) | 191 (179–204) | 106 (101–111) |
p trend (p het) | 0.02 (0.08) | 0.05 (0.39) | 0.35 (0.25) | 0.02 (0.10) | 0.76 (0.53) | 0.81 (0.90) | 0.09 (0.35) | 0.35 (0.05) | |
Characteristics | N | IGF-I | IGFBP-1 | IGFBP-2 | IGFBP-3 | IGFBP-4 | IGFBP-5 | IGFBP-6 | IGFBP-7 |
Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | ||
Oral contraceptive use | |||||||||
Never | 28 | 124 (108–139) | 0.71 (0.06–1.35) | 339 (280–399) | 3372 (3108–3637) | 123 (110–135) | 397 (354–439) | 196 (182–210) | 104 (97–111) |
Former | 165 | 122 (116–127) | 0.82 (0.53–1.10) | 331 (307–356) | 3471 (3366–3575) | 132 (128–137) | 384 (369–399) | 185 (179–192) | 108 (105–111) |
p het | 0.80 | 0.76 | 0.81 | 0.48 | 0.12 | 0.54 | 0.19 | 0.31 | |
Menopausal hormone use | |||||||||
Never | 169 | 123 (118–128) | 0.88 (0.58–1.18) | 342 (317–366) | 3448 (3349–3546) | 130 (126–135) | 387 (371–402) | 189 (183–195) | 107 (104–111) |
Former | 22 | 117 (100–133) | 0.41 (−0.02–0.84) | 267 (210–324) | 3555 (3153–3958) | 132 (118–146) | 372 (338–407) | 177 (157–196) | 109 (101–118) |
p het | 0.45 | 0.15 | 0.03 | 0.50 | 0.81 | 0.53 | 0.18 | 0.69 | |
Family history of breast cancer in a first-degree relative | |||||||||
None | 145 | 124 (118–130) | 0.74 (0.46–1.03) | 331 (305–357) | 3460 (3343–3577) | 131 (126–136) | 390 (373–407) | 186 (179–192) | 107 (103–111) |
1 or more | 47 | 115 (108–123) | 1.08 (0.45–1.71) | 335 (286–385) | 3426 (3258–3594) | 131 (124–138) | 376 (351–400) | 189 (179–202) | 109 (104–114) |
p het | 0.15 | 0.33 | 0.88 | 0.77 | 0.93 | 0.39 | 0.52 | 0.64 | |
Cigarette smoking | |||||||||
Never | 100 | 126 (119–134) | 0.89 (0.49–1.30) | 339 (306–372) | 3462 (3323–3601) | 135 (129–141) | 402 (383–421) | 189 (181–198) | 109 (105–113) |
Former | 65 | 116 (109–124) | 0.77 (0.36–1.18) | 322 (283–360) | 3417 (3264–3570) | 123 (115–131) | 368 (343–393) | 182 (172–192) | 105 (99–111) |
Current | 20 | 118 (101–136) | 0.54 (−0.08–1.16) | 357 (292–423) | 3566 (3215–3917) | 141 (129–153) | 346 (313–379) | 195 (182–207) | 108 (98–118) |
p trend (p het) | 0.12 (0.19) | 0.38 (0.11) | 0.98 (0.65) | 0.79 (0.70) | 0.58 (0.01) | 0.005 (0.02) | 0.85 (0.36) | 0.45 (0.42) | |
Breast biopsy prior to enrollment | |||||||||
Never | 130 | 122 (116–128) | 0.71 (0.43–0.99) | 321 (295–347) | 3433 (3311–3556) | 132 (126–137) | 388 (371–405) | 184 (177–191) | 109 (105–113) |
Ever | 63 | 122 (113–131) | 1.02 (0.45–1.58) | 357 (311–402) | 3504 (3348–3660) | 129 (123–136) | 381 (355–407) | 194 (184–204) | 104 (99–108) |
p het | 0.94 | 0.31 | 0.16 | 0.51 | 0.63 | 0.66 | 0.10 | 0.09 | |
Biopsy diagnosis | |||||||||
Benign non-proliferative | 70 | 119 (111–126) | 0.58 (0.26–0.91) | 310 (277–343) | 3425 (3277–3573) | 137 (128–145) | 401 (375–427) | 180 (171–190) | 107 (101–113) |
Proliferative with/without atypia | 97 | 125 (118–133) | 1.16 (0.66–1.66) | 353 (317–389) | 3467 (3329–3605) | 128 (123–134) | 382 (363–400) | 189 (181–197) | 108 (104–112) |
In situ/invasive | 26 | 119 (102–137) | 0.46 (0.03–0.88) | 321 (264–377) | 3502 (3181–3823) | 124 (113–136) | 361 (324–398) | 198 (183–213) | 107 (100–115) |
p trend (p het) | 0.65 (0.49) | 0.73 (0.07) | 0.38 (0.21) | 0.60 (0.87) | 0.04 (0.10) | 0.07 (0.19) | 0.04 (0.13) | 0.93 (0.97) | |