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Fig. 1 | Breast Cancer Research

Fig. 1

From: Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy

Fig. 1

Schematic representation of the insulin-like growth factor (IGF) system. The IGF system consists of IGF-I and IGF-II, IGF binding proteins (IGFBP-1 to7), and type I and II IGF receptors. IGFBPs have high affinity to IGFs and modulate their access to IGF receptors. IGF proteases dissociate the IGFBP-IGF complex, and the freed IGFs can then bind to the IGF receptors, activating downstream signaling pathways: the phosphatidylinositol-3-kinase and RAS-extracellular signal-regulated kinase pathways. ALS: Acid Labile Subunit

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