Fig. 4

On-treatment signatures more accurately predict pathological response and outcome than pre-treatment. a A greater proportion of patients with pathological response are predicted as responders with estimations of molecular signatures on-treatment than pre-treatment. Concordance between patients predicted as high and low risk across time is poor, but the positive predictive value of these tests increase with treatment. For PAM50 subtypes, normal-like and Luminal A are considered good prognosis and basal/Luminal B/HER2-enriched are considered poor outcome. Red = predicted poor outcome, blue = predicted good outcome. b Forrest plots to compare molecular signatures and AAGAB before and on-treatment combining both datasets, except where indicated* due to individual sample data unavailable for I-SPY 1 patients