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Fig. 1 | Breast Cancer Research

Fig. 1

From: Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation

Fig. 1

Individual swimmer plots for each patient in the overall study population. Depicting progression-free survival (PFS) for PTEN cohort (blue), and PFS for PIK3CA/AKT cohort (red). Patients who discontinued MK-2206 due to toxicity are depicted with a (#), while patients who discontinued MK-2206 due to patient choice are depicted with a (*). Two patients who were enrolled on the PTEN loss cohort had PTEN expressions on the pre-treatment biopsy sample are depicted with a (&). A patient who had both PTEN loss and PIK3CA mutation is depicted with a (^). One patient who had partial response starting at 12 weeks (▲)

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