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Fig. 2 | Breast Cancer Research

Fig. 2

From: Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models

Fig. 2

Transwell co-culture of breast cancer cells with obASCs increases expression of metastatic genes. a TNBC cell line BT20 gene expression was screened for changes in epithelial-to-mesenchymal transition (EMT), inflammatory, and cancer stem cell (CSC) genes after 96-h of transwell co-culture (shown in heat map). b Serpine1, TWIST1, and SNAI2 were evaluated across four cell lines: BT20, HCC1806, MCF7, and TU-BcX-2 K1 PDX-derived cells. Values reported are the mean of three independent experiments each performed in triplicate. Bars, ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001

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