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Table 3 NNMT expression reduces the chemo-sensitivities of human breast cancer cells to ADM and PTX

From: Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization

 

IC50 of ADM (μM)

IC50 of PTX (nM)

Cell lines

Mean ± SEM

Fold change

Mean ± SEM

Fold change

SK-BR-3/Vector

0.12 ± 0.02

 

12.32 ± 1.20

 

SK-BR-3/NNMT-1

0.40 ± 0.05**

3.33

17.41 ± 1.95

1.41

SK-BR-3/NNMT-2

1.00 ± 0.11**

8.33

24.50 ± 2.83*

1.99

MCF7/Vector

0.40 ± 0.05

 

20.12 ± 1.93

 

MCF7/NNMT-1

0.82 ± 0.09*

2.05

28.35 ± 2.14*

1.41

MCF7/NNMT-2

0.92 ± 0.11*

2.30

31.18 ± 3.05*

1.55

MDA-MB-231/NC

1.40 ± 0.09

 

12.40 ± 1.13

 

MDA-MB-231/NNMT shRNA 1#

0.72 ± 0.06**

0.51

7.23 ± 0.78*

0.58

MDA-MB-231/NNMT shRNA 2#

0.61 ± 0.05**

0.44

6.20 ± 0.74*

0.49

  1. Data represent the mean ± SEM of three independent experiments. Statistical significance was detected between the NNMT overexpression or downregulation groups and each matched the control group (SK-BR-3/Vector, MCF/vector or MDA-MB-231/NC)
  2. *p < 0.05, **p < 0.01
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Breast Cancer Research

ISSN: 1465-542X

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