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Fig. 8 | Breast Cancer Research

Fig. 8

From: Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization

Fig. 8

SIRT1 knockdown increases cell viability inhibition by ADM or PTX in NNMT high-expression BCs. Cells were exposed to various concentrations of ADM or PTX for 48 h with SIRT1-specific inhibitor EX527 or SIRT1 siRNA pretreatment, and the viabilities were assessed by CCK8 (n = 3). The group that was pretreated only with DMSO and treated with ddH2O served as the control group for each cell model treated with ADM. The group that was pretreated only with DMSO and treated with DMSO served as the control group for each cell model treated with PTX. a, c, e The viabilities of cells after ADM treatment for 48 h. b, d, f The viabilities of cells after PTX treatment for 48 h

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