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Fig. 5 | Breast Cancer Research

Fig. 5

From: Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization

Fig. 5

NNMT increases SIRT1 protein and activity levels in BCs. ac Overexpression or low expression of NNMT did not significantly change the SIRT1 mRNA level (n = 3) (p > 0.05). d SIRT1, acetyl-p53, and NNMT protein expression was determined by Western blotting. The protein levels were normalized to β-actin. This result is representative of three independent experiments. eg The SIRT1 activity levels were determined using a SIRT1 deacetylase fluorometric reagent kit (n = 3) (**p < 0.01). The group with vector or NC served as the control group for each cell model

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