Table 1 Type of systemic therapies employed as the immediate subsequent therapeutic line after TREnd (physician choice), classified by pharmacological classes

 Capecitabine-containing (n = 30)

Capecitabine

22

Capecitabine + vinorelbine

6

Capecitabine + vinorelbine + cyclophosphamide

2

 Taxane-based (n = 21)

Paclitaxel

20

Paclitaxel + BYL79*

1

 Anthracycline-based (n = 9)

Doxorubicin

1

Epirubicin

1

Doxorubicin + cyclophosphamide

7

 Platinum-containing (n = 2)

Cisplatin

1

Cisplatin + cyclophosphamide

1

 Others (n = 7)

Vinorelbine

3

Cyclophosphamide + methotrexate

2

Cyclophosphamide + vinorelbine

2

 Fulvestrant (n = 20)

20

 AIs (n = 7)

Letrozole

2

Anastrozole

1

Exemestane

4

 AI + mTORi (n = 6)

Exemestane + everolimus

5

Exemestane + everolimus + BYL719*

1

1

1

1