From: Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies
Characteristics | OR* | 95% CI* | P value* | P hete | I2 (95% uncer. int.) | OR§ | 95% CI§ | P value§ | P hete | I2 (95% uncer. int.) |
---|---|---|---|---|---|---|---|---|---|---|
Age at blood draw (years) | ||||||||||
 < 50 | 1.11 | (0.82,1.50) | 0.49 | 0.17 | 0.0 (0.0, 89.5) | 1.04 | (0.72, 1.51) | 0.82 | 0.57 | 0.0 (−) |
 ≥ 50 | 0.89 | (0.81, 0.99) | 0.03 |  | 0.0 (0.0, 75.8) | 0.93 | (0.84, 1.04) | 0.22 |  | 0.0 (0.0, 0.0) |
ER status | ||||||||||
 ER+ | 0.92 | (0.83, 1.02) | 0.10 | 0.88 | 0.0 (0.0, 66.1) | 0.93 | (0.83, 1.05) | 0.25 | 0.46 | 0.07 (0.0, 0.0) |
 ER− | 0.93 | (0.76, 1.15) | 0.51 |  | 40.5 (0.0, 79.9) | 1.04 | (0.81, 1.34) | 0.77 |  | 0.0 (0.0, 83.8) |
Stage†| ||||||||||
 Early | 0.94 | (0.84, 1.06) | 0.34 | 0.20 | 0.0 (0.0, 76.0) | 0.90 | (0.79, 1.03) | 0.13 | 0.68 | 0.0 (0.0, 72.4) |
 Late | 0.83 | (0.71, 0.97) | 0.02 |  | 9.7 (0.0, 86.2) | 0.95 | (0.79, 1.13) | 0.55 |  | 0.0 (0.0, 80.5) |
Time since diagnosis | ||||||||||
 < 2 years | 0.96 | (0.75, 1.24) | 0.78 | 0.68 | 11.4 (0.0, 86.4) | 0.99 | (0.72, 1.37) | 0.96 | 0.80 | 0.0 (0.0, 77.4) |
 ≥ 2 years | 0.91 | (0.83, 1.00) | 0.06 |  | 24.9 (0.0, 88.3) | 0.95 | (0.85, 1.06) | 0.34 |  | 0.0 (0.0, 26.5) |
Time since diagnosis | ||||||||||
 < 5 years | 0.93 | (0.78, 1.10) | 0.39 | 0.98 | 71.4 (18.6, 90.0) | 0.93 | (0.75, 1.14) | 0.47 | 0.99 | 19.4 (0.0, 87.7) |
 ≥ 5 and ≤ 10 years | 0.92 | (0.81, 1.04) | 0.20 |  | 0.0 (0.0, 71.3) | 0.94 | (0.81, 1.08) | 0.37 |  | 0.0 (0.0, 74.0) |
 > 10 years | 0.94 | (0.80, 1.11) | 0.46 |  | 0.0 (0.0, 56.2) | 0.93 | (0.77, 1.12) | 0.46 |  | 0.0 (0.0, 70.6) |
CpG region‡ | ||||||||||
 CpG island | 0.93 | (0.85, 1.02) | 0.13 | 0.98 | 0.0 (0.0, 79.6) | 0.98 | (0.87, 1.10) | 0.74 | 0.95 | 0.0 (0.0, 71.1) |
 CpG shore | 0.92 | (0.84, 1.00) | 0.06 |  | 0.0 (0.0, 23.0) | 0.94 | (0.84, 1.04) | 0.23 |  | 0.0 (0.0, 0.0) |
 CpG shelf | 0.94 | (0.86, 1.03) | 0.20 |  | 58.7 (0.0, 86.3) | 0.96 | (0.86, 1.06) | 0.42 |  | 0.0 (0.0, 27.1) |
 Open sea | 0.94 | (0.86, 1.03) | 0.18 |  | 62.3 (0.0, 87.3) | 0.95 | (0.85, 1.05) | 0.31 |  | 0.0 (0.0, 60.9) |
Regulatory region¶ | ||||||||||
 Promoter | 0.90 | (0.82, 0.99) | 0.03 | 0.95 | 0.0 (0.0, 65.5) | 0.93 | (0.83, 1.04) | 0.20 | 0.96 | 0.0 (0.0, 64.0) |
 Gene body | 0.93 | (0.85, 1.02) | 0.14 |  | 48.1 (0.0, 82.8) | 0.96 | (0.87, 1.07) | 0.46 |  | 0.0 (0.0, 62.3) |
 3′UTR | 0.93 | (0.85, 1.02) | 0.12 |  | 59.8 (0.0, 86.6) | 0.96 | (0.87, 1.07) | 0.50 |  | 0.0 (0.0, 50.8) |
 Intergenic | 0.92 | (0.84, 1.01) | 0.07 |  | 53.7 (0.0, 84.7) | 0.94 | (0.85, 1.04) | 0.27 |  | 0.0 (0.0, 64.4) |