Table 2 Patient’s characteristics
Parameter | CNS metastases as the first site of metastatic disease, N = 108 | Non-CNS metastases as the first site of metastatic disease, N = 411 | Patients without distant relapse, N = 2641 | Overall, N = 3160 |
|---|---|---|---|---|
Age, median (years) | 48.5 | 48.0 | 49.0 | 48.0 |
cT (n, %) | ||||
 cT1–2 | 61 (57.0) | 259 (63.2) | 1986 (75.5) | 2306 (73.3) |
 cT3 | 15 (14.0) | 77 (18.8) | 366 (13.9) | 458 (14.5) |
 cT4a–c | 5 (4.7) | 26 (6.3) | 118 (4.5) | 149 (4.7) |
 cT4d | 26 (24.3) | 48 (11.7) | 161 (6.1) | 235 (7.5) |
 Missing | 1 | 1 | 10 | 12 |
cN (n, %) | ||||
 cN0 | 28 (26.2) | 159 (39.5) | 1394 (53.5) | 1581 (50.8) |
 cN1 | 68 (63.6) | 209 (51.9) | 1100 (42.2) | 1377 (44.2) |
 cN2 | 9 (8.4) | 23 (5.7) | 90 (3.5) | 122 (3.9) |
 cN3 | 2 (1.9) | 12 (3.0) | 20 (0.8) | 34 (1.1) |
 Missing | 1 | 8 | 37 | 46 |
Breast cancer subtype | ||||
 Luminal A-like (grades 1–2) | 11 (10.2) | 107 (26.2) | 836 (31.7) | 954 (30.3) |
 Luminal B-like (grade 3) | 7 (6.5) | 61 (14.9) | 313 (11.9) | 381 (12.1) |
 HER2+ | 34 (31.5) | 76 (18.6) | 699 (26.5) | 809 (25.7) |
 TNBC | 56 (51.9) | 165 (40.3) | 787 (29.9) | 1008 (32.0) |
 Missing | 0 | 2 | 6 | 8 |
Ki67 index (n, %) | ||||
 ≤ 20% | 10 (18.5) | 58 (28.9) | 438 (33.0) | 506 (32.0) |
 > 20% | 44 (81.5) | 143 (71.1) | 888 (67.0) | 1075 (68.0) |
 Missing | 54 | 210 | 1315 | 1579 |
Grade (n, %) | ||||
 G1 | 0 (0.0) | 10 (2.4) | 88 (3.3) | 98 (3.1) |
 G2 | 41 (38.0) | 186 (45.5) | 1305 (49.6) | 1532 (48.7) |
 G3 | 67 (62.0) | 213 (52.1) | 1236 (47.0) | 1516 (48.2) |
 Missing | 0 | 2 | 12 | 14 |
pCR | ||||
 No | 92 (85.2) | 376 (91.5) | 1954 (74.0) | 2422 (76.6) |
 Yes | 16 (14.8) | 35 (8.5) | 687 (26.0) | 738 (23.4) |