Frequency of pathogenic germline variants in BRCA1, BRCA2, PALB2, CHEK2 and TP53 in ductal carcinoma in situ diagnosed in women under the age of 50 years

Table 4 Case only analysis of pathogenic variants in DCIS for family history of breast cancer

Gene	Carriers with FH of BC in first degree relative vs no FH		Carriers with FH of BC in any relative vs no FH
Gene	OR (95% CI)	P	OR (95% CI)	P
BRCA2	4.29 (1.82–10.08)	0.001	4.90 (1.65–14.54)	0.002
CHEK2	0.93 (0.30–2.90)	1	1.76 (0.64–4.86)	0.32
PALB2	14.37 (1.68–123.25)	0.006	5.27 (0.61–45.20)	0.12
BRCA1	8.52 (0.88–82.07)	0.058	3.14 (0.33–30.26)	0.36
TP53	1.40 (0.13–15.47)	1	2.09 (0.19–23.07)	0.62

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